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Details on Person UniProt:P35455 Avp
| Class:Id | ReferenceGeneProduct:96176 |
|---|---|
| _chainChangeLog | signal peptide:1-23 added on Fri February 6 2015;peptide:24-32 added on Fri February 6 2015;chain:36-128 added on Fri February 6 2015;peptide:130-168 added on Fri February 6 2015 |
| _displayName | UniProt:P35455 Avp |
| _timestamp | 2026-02-20 22:35:31 |
| chain | signal peptide:1-23 peptide:24-32 chain:36-128 peptide:130-168 |
| checksum | 234F6D826E0BBEE9 |
| comment | FUNCTION Has a direct antidiuretic action on the kidney, it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2).FUNCTION Specifically binds vasopressin.SUBUNIT Interacts with vasopressin receptors V1bR/AVPR1B (Ki=85 pM), V1aR/AVPR1A (Ki=0.6 nM) and V2R/AVPR2 (Ki=4.9 nM) (By similarity). Interacts with oxytocin receptor (OXTR) (Ki=110 nM) (By similarity).SUBCELLULAR LOCATION Belongs to the vasopressin/oxytocin family. |
| description | recommendedName: Vasopressin-neurophysin 2-copeptin alternativeName: AVP-NPII component recommendedName: Arg-vasopressin alternativeName: Arginine-vasopressin /component component recommendedName: Neurophysin 2 alternativeName: Neurophysin-I /component component recommendedName: Copeptin /component |
| geneName | Avp |
| identifier | P35455 |
| isSequenceChanged | FALSE |
| keyword | Amidation Cleavage on pair of basic residues Disulfide bond Glycoprotein Hormone Reference proteome Secreted Signal Vasoactive Vasoconstrictor |
| modified | [InstanceEdit:143527] Schmidt, EE, 2004-11-12 07:45:10 [InstanceEdit:217385] Schmidt, EE, 2008-03-27 06:23:53 [InstanceEdit:354386] Schmidt, EE, 2008-06-18 04:45:12 [InstanceEdit:384350] Kanapin, AA, 2008-11-26 14:00:39 [InstanceEdit:392885] Kanapin, AA, 2009-03-09 12:07:18 [InstanceEdit:400710] Schmidt, EE, 2009-03-25 05:33:35 [InstanceEdit:423310] Kanapin, AA [InstanceEdit:435478] Kanapin, AA [InstanceEdit:435871] Kanapin, AA [InstanceEdit:447347] Kanapin, AA [InstanceEdit:525883] Kanapin, AA [InstanceEdit:613449] Kanapin, AA [InstanceEdit:797602] Kanapin, AA [InstanceEdit:937368] Yung, CK [InstanceEdit:1042053] Yung, CK [InstanceEdit:1220657] Yung, CK [InstanceEdit:1300696] Yung, CK [InstanceEdit:1301627] Yung, CK [InstanceEdit:1551960] Weiser, JD [InstanceEdit:1995863] Weiser, JD [InstanceEdit:2132304] Weiser, JD [InstanceEdit:2265580] Weiser, JD [InstanceEdit:5433710] Weiser, JD [InstanceEdit:5618415] Weiser, JD [InstanceEdit:5634237] Weiser, JD [InstanceEdit:5673015] Weiser, JD [InstanceEdit:9037114] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9657908] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9983091] Weiser, Joel, 2026-02-20 |
| name | Avp |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | NEU2_MOUSE |
| sequenceLength | 168 |
| species | [Species:48892] Mus musculus |
| (referenceEntity) | [EntityWithAccessionedSequence:879780] Avp [extracellular region] [Mus musculus] |
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No pathways have been reviewed or authored by UniProt:P35455 Avp (96176)
