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Details on Person Activated Ntrk3 stimulates PI3K activity

Class:IdBlackBoxEvent:9616944
_displayNameActivated Ntrk3 stimulates PI3K activity
_doReleaseTRUE
_timestamp2018-08-15 18:09:24
authored[InstanceEdit:9034018] Orlic-Milacic, Marija, 2018-01-02
catalystActivity[CatalystActivity:9603470] 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity of Pik3ca:Pik3r1 [cytosol]
compartment[Compartment:876] plasma membrane
[Compartment:70101] cytosol
created[InstanceEdit:9616943] Orlic-Milacic, Marija, 2018-08-15
edited[InstanceEdit:9608101] Orlic-Milacic, Marija, 2018-05-09
input[SimpleEntity:179856] PI(4,5)P2 [plasma membrane]
[SimpleEntity:113592] ATP [cytosol]
isChimericTRUE
literatureReference[LiteratureReference:9603384] The chimeric protein tyrosine kinase ETV6-NTRK3 requires both Ras-Erk1/2 and PI3-kinase-Akt signaling for fibroblast transformation
[LiteratureReference:9603388] c-Src is required for tropomyosin receptor kinase C (TrkC)-induced activation of the phosphatidylinositol 3-kinase (PI3K)-AKT pathway
modified[InstanceEdit:9616946] Orlic-Milacic, Marija, 2018-08-15
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameActivated Ntrk3 stimulates PI3K activity
output[SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane]
[SimpleEntity:29370] ADP [cytosol]
regulatedBy[PositiveRegulation:9603472] Positive regulation by 'bNTF3:p-5Y-Ntrk3 homodimer:MyrG-p-Y424-Src,(bNTF3:p-5Y-Ntrk3 homodimer,bNTF3:p-5Y-Ntrk3 homodimer:MyrG-p-Y424-Src):Irs1 [plasma membrane]'
releaseDate2018-06-12
reviewed[InstanceEdit:9608098] Tsoulfas, Pantelis, 2018-05-09
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48892] Mus musculus
[Species:48898] Bos taurus
stableIdentifier[StableIdentifier:9616945] R-NUL-9616944.2
summation[Summation:9603475] PI3K signaling in mouse cells is stimulated by Ntrk3 (TrkC) ...
(inferredFrom)[BlackBoxEvent:9603445] Activated NTRK3 stimulates PI3K activity [Homo sapiens]
(replacementInstances)[_Deleted:9616948] Deletion of instance: 9603466
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No pathways have been reviewed or authored by Activated Ntrk3 stimulates PI3K activity (9616944)
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