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Details on Person EGR1 binds CDK5R1 gene

Class:Id	Reaction:9616105
_displayName	EGR1 binds CDK5R1 gene
_doRelease	TRUE
_timestamp	2020-02-27 16:05:08
authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9616104] Rothfels, Karen, 2018-08-09
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
inferredFrom	[Reaction:9616102] Egr1 binds Cdk5r1 gene [Rattus norvegicus]
input	[EntityWithAccessionedSequence:9616090] CDK5R1 gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:1031703] EGR1 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9612004] ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1 [LiteratureReference:8862817] p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5 [LiteratureReference:9616058] A brain-specific activator of cyclin-dependent kinase 5 [LiteratureReference:9616039] The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation [LiteratureReference:9616047] Role of cyclins in neuronal differentiation of immortalized hippocampal cells [LiteratureReference:9616079] Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth
modified	[InstanceEdit:9664635] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665683] Rothfels, Karen, 2019-10-31 [InstanceEdit:9674656] Rothfels, Karen, 2020-01-17 [InstanceEdit:9677119] Rothfels, Karen, 2020-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EGR1 binds CDK5R1 gene
output	[Complex:9616091] CDK5R1 gene:EGR1 [nucleoplasm] [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9616108] R-HSA-9616105.2
summation	[Summation:9616106] EGR1 binds to its cognate site in the promoter element of th...
(hasEvent)	[Pathway:9031628] NGF-stimulated transcription [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9616110] EGR1-dependent CDK5R1 gene expression [Homo sapiens] [Reaction:9616367] NAB2 binds EGR1 to repress CDK5R1 gene expression [Homo sapiens]
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No pathways have been reviewed or authored by EGR1 binds CDK5R1 gene (9616105)