Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person HSPA8 binds substrate

Class:IdReaction:9615721
_displayNameHSPA8 binds substrate
_doReleaseTRUE
_timestamp2020-04-02 10:39:41
authored[InstanceEdit:9637871] Varusai, Thawfeek, 2019-02-21
compartment[Compartment:70101] cytosol
created[InstanceEdit:9615719] Varusai, Thawfeek, 2018-08-08
edited[InstanceEdit:9667290] Varusai, Thawfeek, 2019-11-08
inferredFrom
input[EntityWithAccessionedSequence:264476] HSPA8 [cytosol] [Homo sapiens]
[DefinedSet:9615715] Substrates for chaperone mediated autophagy [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9615711] A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins
[LiteratureReference:9615718] Peptide sequences that target cytosolic proteins for lysosomal proteolysis
[LiteratureReference:9613351] Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis
modified[InstanceEdit:9615731] Varusai, Thawfeek, 2018-08-08
[InstanceEdit:9634384] Varusai, Thawfeek, 2019-01-10
[InstanceEdit:9637992] Varusai, Thawfeek, 2019-02-22
[InstanceEdit:9638325] Varusai, Thawfeek, 2019-03-05
[InstanceEdit:9646683] Varusai, Thawfeek, 2019-05-28
[InstanceEdit:9667360] Varusai, Thawfeek, 2019-11-12
[InstanceEdit:9681506] Varusai, Thawfeek, 2020-04-02
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameHSPA8 binds substrate
output[Complex:9615717] HSPA8 bound autophagic substrates [cytosol] [Homo sapiens]
precedingEvent
releaseDate2019-06-12
reviewed[InstanceEdit:9637993] Metzakopian, Emmanouil, 2019-02-22
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9615730] R-HSA-9615721.5
summation[Summation:9615713] Intracellular proteins are targeted for proteolytic degradat...
(hasEvent)[Pathway:9613829] Chaperone Mediated Autophagy [Homo sapiens]
[Pathway:9615710] Late endosomal microautophagy [Homo sapiens]
[Pathway:9627221] HSPA8-mediated protein degradation [Homo sapiens]
(precedingEvent)[Reaction:9620197] HSPA8:Substrate binds LAMP2a [Homo sapiens]
[Reaction:9631068] HSPA8:substrate binds late endosomal phospholipids [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by HSPA8 binds substrate (9615721)