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Details on Person 14-3-3 proteins bind AKT-phosphorylated FOXO4

Class:Id	Reaction:9614564
_displayName	14-3-3 proteins bind AKT-phosphorylated FOXO4
_doRelease	TRUE
_timestamp	2018-10-31 15:07:19
authored	[InstanceEdit:9624371] Orlic-Milacic, Marija, 2018-10-11
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9614567] Orlic-Milacic, Marija, 2018-07-27
edited	[InstanceEdit:9627016] Orlic-Milacic, Marija, 2018-10-31
input	[EntityWithAccessionedSequence:9614415] p-T32,S197,S262-FOXO4 [cytosol] [Homo sapiens] [Complex:206751] YWHAZ dimer [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9614553] 14-3-3 Protein interacts with nuclear localization sequence of forkhead transcription factor FoxO4 [LiteratureReference:9614557] 14-3-3 protein masks the DNA binding interface of forkhead transcription factor FOXO4 [LiteratureReference:9614543] Both the N-terminal loop and wing W2 of the forkhead domain of transcription factor Foxo4 are important for DNA binding
modified	[InstanceEdit:9614656] Orlic-Milacic, Marija, 2018-07-27 [InstanceEdit:9625981] Orlic-Milacic, Marija, 2018-10-23 [InstanceEdit:9626977] Orlic-Milacic, Marija, 2018-10-30 [InstanceEdit:9626979] Orlic-Milacic, Marija, 2018-10-30 [InstanceEdit:9627002] Orlic-Milacic, Marija, 2018-10-31 [InstanceEdit:9627006] Orlic-Milacic, Marija, 2018-10-31 [InstanceEdit:9627017] Orlic-Milacic, Marija, 2018-10-31 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	14-3-3 proteins bind AKT-phosphorylated FOXO4
output	[Complex:9614653] p-T32,S197,S262-FOXO4:YWHAZ dimer [cytosol] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9614414] AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol [Homo sapiens] [Reaction:199299] AKT phosphorylates FOXO transcription factors [Homo sapiens]
releaseDate	2018-12-13
reviewed	[InstanceEdit:9625979] Donlon, Timothy, 2018-10-17 [InstanceEdit:9626974] Bertaggia, Enrico, 2018-10-26
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9614570] R-HSA-9614564.2
summation	[Summation:9614652] Nuclear exclusion and cytoplasmic retention of AKT-phosphory...
(hasEvent)	[Pathway:9614399] Regulation of localization of FOXO transcription factors [Homo sapiens]
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No pathways have been reviewed or authored by 14-3-3 proteins bind AKT-phosphorylated FOXO4 (9614564)