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Query author contributions in Reactome

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Details on Person Diagram of FOXO-mediated transcription

Class:IdPathwayDiagram:9614394
_displayNameDiagram of FOXO-mediated transcription
_timestamp2020-05-21 20:46:00
created[InstanceEdit:9614393] Orlic-Milacic, Marija, 2018-07-25
height1335
modified[InstanceEdit:9614403] Orlic-Milacic, Marija, 2018-07-26
[InstanceEdit:9614404] Orlic-Milacic, Marija, 2018-07-26
[InstanceEdit:9614406] Orlic-Milacic, Marija, 2018-07-26
[InstanceEdit:9614407] Orlic-Milacic, Marija, 2018-07-26
[InstanceEdit:9614408] Orlic-Milacic, Marija, 2018-07-26
[InstanceEdit:9614421] Orlic-Milacic, Marija, 2018-07-26
[InstanceEdit:9614577] Orlic-Milacic, Marija, 2018-07-27
[InstanceEdit:9614633] Orlic-Milacic, Marija, 2018-07-27
[InstanceEdit:9614656] Orlic-Milacic, Marija, 2018-07-27
[InstanceEdit:9614667] Orlic-Milacic, Marija, 2018-07-27
[InstanceEdit:9614672] Orlic-Milacic, Marija, 2018-07-27
[InstanceEdit:9614675] Orlic-Milacic, Marija, 2018-07-27
[InstanceEdit:9614685] Orlic-Milacic, Marija, 2018-07-27
[InstanceEdit:9614689] Orlic-Milacic, Marija, 2018-07-27
[InstanceEdit:9614700] Orlic-Milacic, Marija, 2018-07-27
[InstanceEdit:9614838] Orlic-Milacic, Marija, 2018-07-30
[InstanceEdit:9614990] Orlic-Milacic, Marija, 2018-07-30
[InstanceEdit:9614993] Orlic-Milacic, Marija, 2018-07-30
[InstanceEdit:9614996] Orlic-Milacic, Marija, 2018-07-30
[InstanceEdit:9615012] Orlic-Milacic, Marija, 2018-07-30
[InstanceEdit:9615013] Orlic-Milacic, Marija, 2018-07-30
[InstanceEdit:9615037] Orlic-Milacic, Marija, 2018-07-30
[InstanceEdit:9615242] Orlic-Milacic, Marija, 2018-07-31
[InstanceEdit:9616331] Orlic-Milacic, Marija, 2018-08-10
[InstanceEdit:9617669] Orlic-Milacic, Marija, 2018-08-30
[InstanceEdit:9617701] Orlic-Milacic, Marija, 2018-08-30
[InstanceEdit:9617716] Orlic-Milacic, Marija, 2018-08-30
[InstanceEdit:9617740] Orlic-Milacic, Marija, 2018-08-30
[InstanceEdit:9617746] Orlic-Milacic, Marija, 2018-08-30
[InstanceEdit:9617751] Orlic-Milacic, Marija, 2018-08-30
[InstanceEdit:9617752] Orlic-Milacic, Marija, 2018-08-30
[InstanceEdit:9617770] Orlic-Milacic, Marija, 2018-08-30
[InstanceEdit:9617830] Orlic-Milacic, Marija, 2018-08-30
[InstanceEdit:9617865] Orlic-Milacic, Marija, 2018-08-30
[InstanceEdit:9617909] Orlic-Milacic, Marija, 2018-08-31
[InstanceEdit:9617915] Orlic-Milacic, Marija, 2018-08-31
[InstanceEdit:9617933] Orlic-Milacic, Marija, 2018-08-31
[InstanceEdit:9618002] Orlic-Milacic, Marija, 2018-08-31
[InstanceEdit:9620529] Orlic-Milacic, Marija, 2018-09-25
[InstanceEdit:9620530] Orlic-Milacic, Marija, 2018-09-25
[InstanceEdit:9620535] Orlic-Milacic, Marija, 2018-09-25
[InstanceEdit:9620536] Orlic-Milacic, Marija, 2018-09-25
[InstanceEdit:9620782] Orlic-Milacic, Marija, 2018-09-25
[InstanceEdit:9621311] Orlic-Milacic, Marija, 2018-09-26
[InstanceEdit:9621562] Orlic-Milacic, Marija, 2018-09-26
[InstanceEdit:9621696] Orlic-Milacic, Marija, 2018-09-27
[InstanceEdit:9621699] Orlic-Milacic, Marija, 2018-09-27
[InstanceEdit:9621791] Orlic-Milacic, Marija, 2018-09-27
[InstanceEdit:9621816] Orlic-Milacic, Marija, 2018-09-27
[InstanceEdit:9621842] Orlic-Milacic, Marija, 2018-09-27
[InstanceEdit:9621876] Orlic-Milacic, Marija, 2018-09-27
[InstanceEdit:9621921] Orlic-Milacic, Marija, 2018-09-27
[InstanceEdit:9621960] Orlic-Milacic, Marija, 2018-09-27
[InstanceEdit:9622119] Orlic-Milacic, Marija, 2018-09-28
[InstanceEdit:9622128] Orlic-Milacic, Marija, 2018-09-28
[InstanceEdit:9622912] Orlic-Milacic, Marija, 2018-10-02
[InstanceEdit:9623184] Orlic-Milacic, Marija, 2018-10-03
[InstanceEdit:9623900] Orlic-Milacic, Marija, 2018-10-05
[InstanceEdit:9623915] Orlic-Milacic, Marija, 2018-10-05
[InstanceEdit:9626937] Orlic-Milacic, Marija, 2018-10-30
[InstanceEdit:9626938] Orlic-Milacic, Marija, 2018-10-30
[InstanceEdit:9626958] Orlic-Milacic, Marija, 2018-10-30
[InstanceEdit:9626959] Orlic-Milacic, Marija, 2018-10-30
[InstanceEdit:9626965] Orlic-Milacic, Marija, 2018-10-30
[InstanceEdit:9627453] Orlic-Milacic, Marija, 2018-11-02
[InstanceEdit:9628559] Orlic-Milacic, Marija, 2018-11-09
[InstanceEdit:9645116] Wu, G, 2019-05-03
[InstanceEdit:9658476] Orlic-Milacic, Marija, 2019-08-14
[InstanceEdit:9688537] Matthews, Lisa, 2020-05-14
[InstanceEdit:9689792] Matthews, Lisa, 2020-05-21
representedPathway[Pathway:9614085] FOXO-mediated transcription [Homo sapiens]
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textPosition="1762 764" /> <org.gk.render.RenderableChemical id="666" reactomeId="427523" position="1852 774" bounds="1829 761 46 27" textPosition="1830 764"> <Properties> <displayName>NAD+</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="667" reactomeId="427498" position="1833 709" bounds="1783 688 100 42" textPosition="1792 691"> <Properties> <displayName>2'-O-acetyl-ADP-ribose</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="668" reactomeId="427497" position="1857 643" bounds="1835 630 45 27" textPosition="1839 633" /> <org.gk.render.ProcessNode id="680" reactomeId="9614657" position="1353 286" bounds="1273 255 161 63" textPosition="1286 258"> <Properties> <displayName>FOXO-mediated transcription of cell death genes</displayName> </Properties> </org.gk.render.ProcessNode> <org.gk.render.RenderableGene id="708" reactomeId="8948480" position="1860 337" bounds="1820 312 81 51" textPosition="1820 339"> <Properties> <displayName>FOXO3 gene</displayName> </Properties> </org.gk.render.RenderableGene> <org.gk.render.RenderableRNA id="709" reactomeId="9621305" position="2151 216" bounds="2104 198 95 37" textPosition="2107 206"> <Properties> <displayName>FOXO3 mRNA</displayName> </Properties> </org.gk.render.RenderableRNA> <org.gk.render.RenderableComplex id="710" reactomeId="9621304" position="1970 239" bounds="1953 228 35 22" textPosition="1953 229" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>HIF1</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="722" reactomeId="9022629" position="1808 385" bounds="1782 373 52 25" textPosition="1784 375"> <Properties> <displayName>FOXG1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="723" reactomeId="452271" position="1842 423" bounds="1822 412 41 22" textPosition="1823 412"> <Properties> <displayName>SOX2</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="724" reactomeId="9621681" position="1968 474" bounds="1922 456 93 37" textPosition="1925 458" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>FOXG1:SOX2:FOXO3 gene</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="741" reactomeId="8858586" position="2384 314" bounds="2345 303 79 22" textPosition="2346 304" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>BMP4 dimer</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableComplex id="1003" reactomeId="9621541" position="2163 548" bounds="2128 474 70 148" textPosition="2128 475" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>FOXO3 mRNA:miR-9,miR-132,miR-155,miR-182,miR-212,miR-223,(miR-708) RISC</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableEntitySet id="1098" reactomeId="9621445" position="2244 396" bounds="2210 331 68 130" textPosition="2210 330" bgColor="204 255 255" fgColor="0 0 0" lineColor="0 0 0" lineWidth="1.0"> <Properties> <displayName>miR-9,miR-132,miR-155,miR182,miR-212,miR-223 RISC,(miR-708 RISC)</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableEntitySet id="1104" reactomeId="9622899" position="2000 735" bounds="1972 720 56 30" textPosition="1978 718"> <Properties> <displayName>SIRT1,SIRT3</displayName> </Properties> </org.gk.render.RenderableEntitySet> <org.gk.render.RenderableProtein id="1131" reactomeId="193545" position="1627 895" bounds="1601 884 53 22" textPosition="1602 884"> <Properties> <displayName>CREBBP</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1133" reactomeId="199300" position="1761 977" bounds="1736 966 51 22" textPosition="1737 966"> <Properties> <displayName>FOXO1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableComplex id="1136" reactomeId="9626931" position="1296 1114" bounds="1263 1097 67 34" textPosition="1270 1096" bgColor="204 255 255" hideComponents="true"> <Properties> <displayName>FOXO1:CREBBP</displayName> </Properties> </org.gk.render.RenderableComplex> <org.gk.render.RenderableProtein id="1192" reactomeId="9626942" position="1690 1143" bounds="1591 1129 199 29" textPosition="1602 1133"> <Properties> <displayName>Ac-K245,K248,K265-FOXO1</displayName> </Properties> <NodeAttachments> <org.gk.render.RenderableFeature relativeX="0.0" relativeY="0.2540244981102555" label="Ac" description="Lys" trackId="0" reactomeId="9626943" /> <org.gk.render.RenderableFeature relativeX="0.23724329201984895" relativeY="1.0" label="Ac" description="Lys" trackId="0" reactomeId="9626946" /> <org.gk.render.RenderableFeature relativeX="0.07918552036199095" relativeY="1.0" label="Ac" description="Lys" trackId="0" reactomeId="9626947" /> </NodeAttachments> </org.gk.render.RenderableProtein> <org.gk.render.RenderableProtein id="1233" reactomeId="427531" position="1965 1086" bounds="1944 1075 42 22" textPosition="1945 1075"> <Properties> <displayName>SIRT1</displayName> </Properties> </org.gk.render.RenderableProtein> <org.gk.render.RenderableChemical id="1236" reactomeId="427523" position="1928 1139" bounds="1905 1126 46 27" textPosition="1906 1129" /> <org.gk.render.RenderableChemical id="1238" reactomeId="427497" position="1929 1029" bounds="1907 1016 45 27" textPosition="1911 1019"> <Properties> <displayName>NAM</displayName> </Properties> </org.gk.render.RenderableChemical> <org.gk.render.RenderableChemical id="1240" reactomeId="427498" position="1855 942" bounds="1805 921 100 42" textPosition="1814 924" /> </Nodes> <Edges> <org.gk.render.RenderableReaction id="10" reactomeId="199299" points="1072 404, 1038 402, 1003 404" position="1038 402" lineWidth="1.0"> <Inputs> <Input id="12" stoichiometry="3" points="1076 449" /> <Input id="282" points="1117 400" /> </Inputs> <Outputs> <Output id="289" stoichiometry="3" points="994 452" /> <Output id="287" points="947 401" /> </Outputs> <Catalysts> <Catalyst id="15" points="1038 359" /> </Catalysts> <Properties> <displayName>AKT phosphorylates FOXO transcription factors</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="17" interactionType="Activate" points="1035 78, 1037 325" position="1036 201" lineWidth="2.0"> <Inputs> <Input id="16" /> </Inputs> <Outputs> <Output id="15" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="57" reactomeId="9614414" points="745 492, 716 492, 668 490" position="716 492" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="13" /> </Inputs> <Outputs> <Output id="58" /> </Outputs> <Properties> <displayName>AKT-phosphorylated FOXO1,FOXO3,FOXO4 translocate to the cytosol</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="86" reactomeId="9614423" points="402 275, 435 268, 470 264" position="435 268" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="87" points="340 330" /> <Input id="89" points="362 261" /> </Inputs> <Outputs> <Output id="90" /> </Outputs> <Properties> <displayName>14-3-3 proteins bind AKT-phosphorylated FOXO1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="88" points="354 370, 522 454" position="438 412" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="87" /> </Inputs> <Outputs> <Output id="58" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="102" reactomeId="9614562" points="277 548, 277 578, 278 614" position="277 578" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="103" points="231 514" /> <Input id="105" points="336 506" /> </Inputs> <Outputs> <Output id="107" /> </Outputs> <Properties> <displayName>14-3-3 proteins bind AKT-phosphorylated FOXO3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="104" points="199 446, 196 247, 248 247" position="196 247" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="103" /> </Inputs> <Outputs> <Output id="89" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.EntitySetAndMemberLink id="106" points="444 486, 486 487" position="465 486" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="105" /> </Inputs> <Outputs> <Output id="58" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="114" reactomeId="9614564" points="267 822, 267 852, 269 895" position="267 852" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="115" points="302 783" /> <Input id="117" points="171 797" /> </Inputs> <Outputs> <Output id="120" /> </Outputs> <Properties> <displayName>14-3-3 proteins bind AKT-phosphorylated FOXO4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="116" points="329 747, 549 524" position="439 635" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="115" /> </Inputs> <Outputs> <Output id="58" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="118" points="136 769, 193 514" position="164 641" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="117" /> </Inputs> <Outputs> <Output id="103" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="119" points="133 769, 129 214, 248 237" position="129 214" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="117" /> </Inputs> <Outputs> <Output id="89" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="181" points="1357 359, 1191 392" position="1274 375" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="180" /> </Inputs> <Outputs> <Output id="282" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="265" reactomeId="9614716" points="1859 122, 1796 120, 1730 122" position="1796 120" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="267" points="1949 124" /> <Input id="266" points="1867 144" /> </Inputs> <Outputs> <Output id="268" /> </Outputs> <Properties> <displayName>microRNAs bind FOXO4 mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="275" reactomeId="9614705" points="1829 162, 1781 168, 1403 343" position="1781 168" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="266" /> </Inputs> <Outputs> <Output id="180" /> </Outputs> <Inhibitors> <Inhibitor id="268" points="1730 133, 1772 139" /> </Inhibitors> <Properties> <displayName>FOXO4 mRNA translation is inhibited by micrRNAs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndEntitySetLink id="288" points="843 440, 839 460" position="841 450" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="287" /> </Inputs> <Outputs> <Output id="13" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="324" reactomeId="9617660" points="1393 481, 1392 527, 1393 563" position="1392 527" lineWidth="1.0"> <Inputs> <Input id="180" points="1384 367" /> <Input id="325" points="1530 533" /> </Inputs> <Outputs> <Output id="326" /> </Outputs> <Properties> <displayName>ROS oxidize FOXO4 cysteine residues</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="381" reactomeId="9617683" points="1440 637, 1423 666, 1409 707" position="1423 666" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="382" points="1492 643" /> <Input id="326" stoichiometry="2" points="1409 605" /> </Inputs> <Outputs> <Output id="383" /> </Outputs> <Properties> <displayName>EP300,CREBBP bind SOH-C481-FOXO4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="440" reactomeId="9617735" points="1217 727, 1227 670, 1303 518" position="1227 670" lineWidth="1.0"> <Inputs> <Input id="441" points="1159 747" /> <Input id="451" points="1225 790" /> </Inputs> <Outputs> <Output id="442" points="1228 561" /> <Output id="180" points="1379 367" /> <Output id="453" points="1288 650" /> </Outputs> <Catalysts> <Catalyst id="441" points="1139 739, 1172 673" /> </Catalysts> <Inhibitors> <Inhibitor id="469" points="1180 645" /> </Inhibitors> <Properties> <displayName>TXN disrupts FOXO4 complex with EP300</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="452" points="1259 790, 1351 760" position="1305 775" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="451" /> </Inputs> <Outputs> <Output id="383" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="454" points="1314 662, 1492 649" position="1403 655" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="453" /> </Inputs> <Outputs> <Output id="382" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="488" reactomeId="9617758" points="1377 817, 1393 829, 1432 830" position="1393 829" lineWidth="1.0"> <Inputs> <Input id="383" points="1396 760" /> <Input id="489" stoichiometry="2" points="1300 840" /> </Inputs> <Outputs> <Output id="490" stoichiometry="2" points="1500 843" /> <Output id="382" points="1531 671, 1565 795" /> <Output id="491" stoichiometry="2" points="1445 896" /> </Outputs> <Catalysts> <Catalyst id="383" points="1409 760, 1417 780" /> </Catalysts> <Properties> <displayName>EP300,CREBBP acetylate FOXO4</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="598" interactionType="Activate" points="1154 362, 1154 317" position="1154 339" lineWidth="2.0"> <Inputs> <Input id="282" /> </Inputs> <Outputs> <Output id="596" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableInteraction id="600" interactionType="Activate" points="1132 434, 973 655" position="1052 544" lineWidth="2.0"> <Inputs> <Input id="282" /> </Inputs> <Outputs> <Output id="599" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="617" reactomeId="9620515" points="1705 672, 1708 715, 1706 787" position="1708 715" lineWidth="1.0"> <Inputs> <Input id="618" points="1821 526" /> <Input id="640" stoichiometry="5" points="1753 651" /> </Inputs> <Outputs> <Output id="621" points="1791 864" /> <Output id="642" stoichiometry="5" points="1755 779" /> </Outputs> <Catalysts> <Catalyst id="622" points="1670 707" /> </Catalysts> <Activators> <Activator id="325" points="1564 557" /> </Activators> <Properties> <displayName>KAT2B,EP300 acetylate FOXO3 under oxidative stress</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="620" points="1801 512, 1137 517, 1149 434" position="1137 517" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="618" /> </Inputs> <Outputs> <Output id="282" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="623" points="1314 666, 1601 698" position="1457 682" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="453" /> </Inputs> <Outputs> <Output id="622" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndEntitySetLink id="624" points="1601 686, 1563 662" position="1582 674" lineWidth="0.5" lineColor="128 128 128"> <Inputs> <Input id="622" /> </Inputs> <Outputs> <Output id="382" /> </Outputs> </org.gk.render.EntitySetAndEntitySetLink> <org.gk.render.RenderableReaction id="665" reactomeId="9620532" points="1901 814, 1922 736, 1921 656" position="1922 736" lineWidth="1.0"> <Inputs> <Input id="621" points="1832 864" /> <Input id="666" stoichiometry="5" points="1868 791" /> </Inputs> <Outputs> <Output id="667" stoichiometry="5" points="1867 685" /> <Output id="668" stoichiometry="5" points="1883 647" /> <Output id="618" points="1836 526" /> </Outputs> <Catalysts> <Catalyst id="1104" points="1966 735" /> </Catalysts> <Properties> <displayName>SIRT1,SIRT3 deacetylate FOXO3</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableInteraction id="681" interactionType="Activate" points="1191 381, 1299 321" position="1245 351" lineWidth="2.0"> <Inputs> <Input id="282" /> </Inputs> <Outputs> <Output id="680" /> </Outputs> </org.gk.render.RenderableInteraction> <org.gk.render.RenderableReaction id="707" reactomeId="9621300" points="1910 314, 2009 278, 2108 230" position="2009 278" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="708" /> </Inputs> <Outputs> <Output id="709" /> </Outputs> <Activators> <Activator id="710" points="1981 253" /> </Activators> <Properties> <displayName>FOXO3 gene transcription is stimulated by HIF1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="721" reactomeId="9621670" points="1909 377, 1914 413, 1951 453" position="1914 413" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="708" points="1910 314" /> <Input id="722" points="1837 382" /> <Input id="723" points="1858 409" /> </Inputs> <Outputs> <Output id="724" /> </Outputs> <Properties> <displayName>FOXG1 and SOX2 bind FOXO3 gene</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="730" reactomeId="9621672" points="1910 314, 2015 295, 2119 230" position="2015 295" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="708" /> </Inputs> <Outputs> <Output id="709" /> </Outputs> <Inhibitors> <Inhibitor id="724" points="1972 453" /> </Inhibitors> <Activators> <Activator id="741" points="2342 311" /> </Activators> <Properties> <displayName>FOXO3 gene transcription is inhibited by FOXG1 and SOX2</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1001" reactomeId="9621429" points="2135 391, 2162 419, 2162 471" position="2162 419" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="709" points="2149 230" /> <Input id="1098" points="2204 394" /> </Inputs> <Outputs> <Output id="1003" /> </Outputs> <Properties> <displayName>microRNAs bind FOXO3 mRNA</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1096" reactomeId="9621447" points="2146 230, 2086 505, 1859 511" position="2086 505" lineWidth="1.0" reactionType="Omitted Process"> <Inputs> <Input id="709" /> </Inputs> <Outputs> <Output id="618" /> </Outputs> <Inhibitors> <Inhibitor id="1003" points="2125 528" /> </Inhibitors> <Properties> <displayName>FOXO3 mRNA translation is inhibited by microRNAs</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1130" reactomeId="9626928" points="1704 1010, 1568 1104, 1333 1112" position="1568 1104" lineWidth="1.0" reactionType="Association"> <Inputs> <Input id="1131" points="1634 909" /> <Input id="1133" points="1742 991" /> </Inputs> <Outputs> <Output id="1136" /> </Outputs> <Properties> <displayName>CREBBP binds FOXO1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1132" points="1622 881, 1534 671" position="1578 776" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1131" /> </Inputs> <Outputs> <Output id="382" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.EntitySetAndMemberLink id="1135" points="1733 977, 1031 995, 1095 543, 1141 434" position="1063 769" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1133" /> </Inputs> <Outputs> <Output id="282" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> <org.gk.render.RenderableReaction id="1191" reactomeId="9626945" points="1376 1005, 1460 1017, 1569 1009" position="1460 1017" lineWidth="1.0"> <Inputs> <Input id="489" stoichiometry="3" points="1275 867" /> <Input id="1136" points="1308 1094" /> </Inputs> <Outputs> <Output id="490" stoichiometry="3" points="1537 867" /> <Output id="1131" points="1621 909" /> <Output id="1192" points="1676 1126" /> </Outputs> <Catalysts> <Catalyst id="1136" points="1333 1104, 1462 1067" /> </Catalysts> <Properties> <displayName>CREBBP acetylates FOXO1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.RenderableReaction id="1232" reactomeId="9626962" points="1845 1146, 1849 1092, 1853 1047" position="1849 1092" lineWidth="1.0"> <Inputs> <Input id="1192" points="1793 1144" /> <Input id="1236" stoichiometry="3" points="1902 1140" /> </Inputs> <Outputs> <Output id="1133" points="1775 991" /> <Output id="1238" stoichiometry="3" points="1904 1034" /> <Output id="1240" stoichiometry="3" points="1854 966" /> </Outputs> <Catalysts> <Catalyst id="1233" points="1941 1087" /> </Catalysts> <Properties> <displayName>SIRT1 deacetylates FOXO1</displayName> </Properties> </org.gk.render.RenderableReaction> <org.gk.render.EntitySetAndMemberLink id="1234" points="1966 1072, 1998 756" position="1982 914" lineWidth="0.5" lineColor="0 0 0"> <Inputs> <Input id="1233" /> </Inputs> <Outputs> <Output id="1104" /> </Outputs> </org.gk.render.EntitySetAndMemberLink> </Edges> <Pathways /> </Process>
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No pathways have been reviewed or authored by Diagram of FOXO-mediated transcription (9614394)
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