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Details on Person Tegument proteins help deliver the Human Cytomegalovirus (HC...

Class:IdSummation:9614371
_displayNameTegument proteins help deliver the Human Cytomegalovirus (HC...
_timestamp2019-10-04 21:09:43
created[InstanceEdit:9614368] Gillespie, Marc E, 2018-07-24
literatureReference[LiteratureReference:9614340] Microtubule network facilitates nuclear targeting of human cytomegalovirus capsid
[Book:9609668] Fields Virology 1451105630 Knipe, David Mahan Chapter 62 - Cytomegaloviruses
[LiteratureReference:9652659] Herpesvirus interactions with the host cytoskeleton
modified[InstanceEdit:9652682] Gillespie, Marc E, 2019-07-02
[InstanceEdit:9663588] Gillespie, Marc E, 2019-10-04
textTegument proteins help deliver the Human Cytomegalovirus (HCMV) genome-containing capsid to the nucleus during the viral entry process. Signals initiated upon receptor binding induce cellular antiviral responses but may also prime the cell for subsequent events during viral entry. The Capsid-associated tegument proteins UL47 and UL48 (and perhaps pp150) direct capsids along microtubules (MTs) toward nuclear pore complexes driven by cellular motor proteins such as dynein.
(summation)[Reaction:9614343] Viral UL47:UL48 Proteins Bind HCMV Tegumented Virion to Host Microtuble and Dynein complexs [Homo sapiens]
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