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Details on Person EGR2 gene expression

Class:Id	BlackBoxEvent:9613760
_displayName	EGR2 gene expression
_doRelease	TRUE
_timestamp	2020-02-27 16:00:40
authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9613764] Rothfels, Karen, 2018-07-18
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
input	[EntityWithAccessionedSequence:9612057] EGR2 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9612009] Early growth response 1--a transcription factor in the crossfire of signal transduction cascades [LiteratureReference:9612019] Gene regulation in the immediate-early response process [LiteratureReference:9611984] Activation and function of immediate-early genes in the nervous system [LiteratureReference:9612028] Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins [LiteratureReference:9612035] The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience [LiteratureReference:9613705] The molecular machinery of myelin gene transcription in Schwann cells [LiteratureReference:9614302] Krox-20 controls myelination in the peripheral nervous system [LiteratureReference:9614264] Characterisation of cis-acting sequences reveals a biphasic, axon-dependent regulation of Krox20 during Schwann cell development [LiteratureReference:9613749] Control of myelination in Schwann cells: a Krox20 cis-regulatory element integrates Oct6, Brn2 and Sox10 activities [LiteratureReference:9614261] Activation of Krox20 gene expression by Sox10 in myelinating Schwann cells [LiteratureReference:9613933] HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells [LiteratureReference:9614286] HDAC-mediated deacetylation of NF-κB is critical for Schwann cell myelination [LiteratureReference:9613916] Chromatin-remodeling factor Brg1 is required for Schwann cell differentiation and myelination
modified	[InstanceEdit:9614322] Rothfels, Karen, 2018-07-24 [InstanceEdit:9614646] Rothfels, Karen, 2018-07-27 [InstanceEdit:9664638] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665683] Rothfels, Karen, 2019-10-31 [InstanceEdit:9674656] Rothfels, Karen, 2020-01-17 [InstanceEdit:9677117] Rothfels, Karen, 2020-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EGR2 gene expression
output	[EntityWithAccessionedSequence:977385] EGR2 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9613768] SOX10, POU3F1 and POU3F2 bind EGR2 gene [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9613762] Positive gene expression regulation by 'EGR2 gene:POU3F1:POU3F2:SOX10 [nucleoplasm]'
releaseDate	2020-03-17
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9613766] R-HSA-9613760.2
summation	[Summation:9614308] EGR2 (also known as KROX20) is a member of the Early Growth ...
(hasEvent)	[Pathway:9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination [Homo sapiens]
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No pathways have been reviewed or authored by EGR2 gene expression (9613760)