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Details on Person SOX10 dimer binds the POU3F1 promoter

Class:Id	Reaction:9613648
_displayName	SOX10 dimer binds the POU3F1 promoter
_doRelease	TRUE
_timestamp	2020-02-27 16:01:24
authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9613649] Rothfels, Karen, 2018-07-16
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
inferredFrom	[Reaction:9614293] Sox10 and Hdac2 interact to regulate expression of genes involved in peripheral myelination [Rattus norvegicus]
input	[EntityWithAccessionedSequence:9613637] POU3F1 gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9613639] SOX10 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9613639] SOX10 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:205135] HDAC2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:201686] SMARCA4 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9613737] Functional dissection of the Oct6 Schwann cell enhancer reveals an essential role for dimeric Sox10 binding [LiteratureReference:9613936] Hypomorphic Sox10 alleles reveal novel protein functions and unravel developmental differences in glial lineages [LiteratureReference:9613905] A cell type-specific allele of the POU gene Oct-6 reveals Schwann cell autonomous function in nerve development and regeneration [LiteratureReference:9613911] A distal Schwann cell-specific enhancer mediates axonal regulation of the Oct-6 transcription factor during peripheral nerve development and regeneration [LiteratureReference:9613933] HDAC1 and HDAC2 control the transcriptional program of myelination and the survival of Schwann cells [LiteratureReference:9613916] Chromatin-remodeling factor Brg1 is required for Schwann cell differentiation and myelination [LiteratureReference:9613705] The molecular machinery of myelin gene transcription in Schwann cells [LiteratureReference:9613718] Schwann cells and their transcriptional network: Evolution of key regulators of peripheral myelination
modified	[InstanceEdit:9614325] Rothfels, Karen, 2018-07-24 [InstanceEdit:9664638] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665683] Rothfels, Karen, 2019-10-31 [InstanceEdit:9674656] Rothfels, Karen, 2020-01-17 [InstanceEdit:9677117] Rothfels, Karen, 2020-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SOX10 dimer binds the POU3F1 promoter
output	[Complex:9613641] POU3F1 gene:SOX10 dimer:HDAC2:SMARCA4 [nucleoplasm] [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9613650] R-HSA-9613648.2
summation	[Summation:9614289] SOX10 binds as a dimer to the Schwann cell enhancer (SCE) el...
(hasEvent)	[Pathway:9619665] EGR2 and SOX10-mediated initiation of Schwann cell myelination [Homo sapiens]
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