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Details on Person EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions

Class:Id	Reaction:9613476
_displayName	EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions
_doRelease	TRUE
_timestamp	2020-02-27 16:05:29
authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9613477] Rothfels, Karen, 2018-07-13
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
input	[DefinedSet:9612537] ID2, ID4 gene [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:977385] EGR2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9612177] NAB2 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:3702078] CHD4 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9613418] Reciprocal Id expression and myelin gene regulation in Schwann cells [LiteratureReference:9613438] The transcription factors SCIP and Krox-20 mark distinct stages and cell fates in Schwann cell differentiation [LiteratureReference:9613103] Nab proteins are essential for peripheral nervous system myelination [LiteratureReference:9613434] Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination [LiteratureReference:9613066] Active gene repression by the Egr2.NAB complex during peripheral nerve myelination [LiteratureReference:9613097] NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex
modified	[InstanceEdit:9622013] Rothfels, Karen, 2018-09-28 [InstanceEdit:9664638] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665683] Rothfels, Karen, 2019-10-31 [InstanceEdit:9674656] Rothfels, Karen, 2020-01-17 [InstanceEdit:9677119] Rothfels, Karen, 2020-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions
output	[Complex:9613463] ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm] [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9613478] R-HSA-9613476.2
summation	[Summation:9613475] EGR2 is required for peripheral nerve cell myelination in Sc...
(hasEvent)	[Pathway:9031628] NGF-stimulated transcription [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9612534] Expression of ID2 and ID4 is repressed by EGR2:NAB [Homo sapiens]
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No pathways have been reviewed or authored by EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions (9613476)