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Details on Person NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression

Class:Id	Reaction:9613213
_displayName	NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression
_doRelease	TRUE
_timestamp	2020-02-27 16:05:48
authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9613214] Rothfels, Karen, 2018-07-11
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
input	[EntityWithAccessionedSequence:3702078] CHD4 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9612177] NAB2 [nucleoplasm] [Homo sapiens] [Complex:9613167] RRAD gene:EGR2 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9612329] NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli [LiteratureReference:9612479] Nab1, a corepressor of NGFI-A (Egr-1), contains an active transcriptional repression domain [LiteratureReference:9613097] NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex [LiteratureReference:9613066] Active gene repression by the Egr2.NAB complex during peripheral nerve myelination [LiteratureReference:9613095] Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation [LiteratureReference:9613126] Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart [LiteratureReference:9613122] Rad GTPase deficiency leads to cardiac hypertrophy [LiteratureReference:9613147] The GTP binding proteins Gem and Rad are negative regulators of the Rho-Rho kinase pathway [LiteratureReference:9613105] Neurotrophins regulate Schwann cell migration by activating divergent signaling pathways dependent on Rho GTPases [LiteratureReference:9613144] Rho kinase regulates schwann cell myelination and formation of associated axonal domains
modified	[InstanceEdit:9622025] Rothfels, Karen, 2018-09-28 [InstanceEdit:9664638] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665683] Rothfels, Karen, 2019-10-31 [InstanceEdit:9674656] Rothfels, Karen, 2020-01-17 [InstanceEdit:9677119] Rothfels, Karen, 2020-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression
output	[Complex:9613187] RRAD gene:EGR2:NAB2:CHD4 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9613210] EGR1, EGR2 bind the RRAD promoter [Homo sapiens] [BlackBoxEvent:9612516] EGR1 gene expression [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9613215] R-HSA-9613213.2
summation	[Summation:9613212] NAB2 is recruited to EGR2 to the RRAD promoter through inter...
(hasEvent)	[Pathway:9031628] NGF-stimulated transcription [Homo sapiens]
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No pathways have been reviewed or authored by NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression (9613213)