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Details on Person EGR1, EGR2 bind the RRAD promoter

Class:Id	Reaction:9613210
_displayName	EGR1, EGR2 bind the RRAD promoter
_doRelease	TRUE
_timestamp	2020-02-27 16:05:22
authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9613209] Rothfels, Karen, 2018-07-11
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
input	[EntityWithAccessionedSequence:9613162] RRAD gene [nucleoplasm] [Homo sapiens] [DefinedSet:9613165] EGR1,EGR2 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9613066] Active gene repression by the Egr2.NAB complex during peripheral nerve myelination [LiteratureReference:9613077] EGR1 target genes in prostate carcinoma cells identified by microarray analysis [LiteratureReference:9613095] Interaction of the Ras-related protein associated with diabetes rad and the putative tumor metastasis suppressor NM23 provides a novel mechanism of GTPase regulation [LiteratureReference:9613122] Rad GTPase deficiency leads to cardiac hypertrophy [LiteratureReference:9613126] Rad as a novel regulator of excitation-contraction coupling and beta-adrenergic signaling in heart
modified	[InstanceEdit:9664638] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665683] Rothfels, Karen, 2019-10-31 [InstanceEdit:9674656] Rothfels, Karen, 2020-01-17 [InstanceEdit:9676944] Rothfels, Karen, 2020-02-24 [InstanceEdit:9677119] Rothfels, Karen, 2020-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EGR1, EGR2 bind the RRAD promoter
output	[DefinedSet:9613169] RRAD gene:EGR1,EGR2 [nucleoplasm] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9612516] EGR1 gene expression [Homo sapiens] [Reaction:9612514] p-S133 CREB and p-S103 SRF bind the EGR1 promoter [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9613211] R-HSA-9613210.2
summation	[Summation:9613200] EGR1 and EGR2 are required for the activation of RRAD gene e...
(hasEvent)	[Pathway:9031628] NGF-stimulated transcription [Homo sapiens]
(precedingEvent)	[Reaction:9613213] NAB2 and CHD4 bind and repress EGR-mediated RRAD gene expression [Homo sapiens]
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No pathways have been reviewed or authored by EGR1, EGR2 bind the RRAD promoter (9613210)