Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Details on Person EGR1 and NAB co-repressors bind EGR1 gene

Class:Id	Reaction:9613202
_displayName	EGR1 and NAB co-repressors bind EGR1 gene
_doRelease	TRUE
_timestamp	2020-02-27 16:05:06
authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9613203] Rothfels, Karen, 2018-07-11
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
input	[EntityWithAccessionedSequence:1031703] EGR1 [nucleoplasm] [Homo sapiens] [EntityWithAccessionedSequence:9034181] EGR1 gene [nucleoplasm] [Homo sapiens] [DefinedSet:9612546] NAB1,2 [nucleoplasm] [Homo sapiens] [DefinedSet:9612546] NAB1,2 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9613156] Transcriptional activity of the zinc finger protein NGFI-A is influenced by its interaction with a cellular factor [LiteratureReference:9612022] Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription [LiteratureReference:9612329] NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli [LiteratureReference:9612470] Egr-1 induces the expression of its corepressor nab2 by activation of the nab2 promoter thereby establishing a negative feedback loop [LiteratureReference:9612464] EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin [LiteratureReference:9613097] NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex [LiteratureReference:9612481] Novel mutants of NAB corepressors enhance activation by Egr transactivators [LiteratureReference:9612461] A novel activation function for NAB proteins in EGR-dependent transcription of the luteinizing hormone beta gene [LiteratureReference:9613103] Nab proteins are essential for peripheral nervous system myelination
modified	[InstanceEdit:9664634] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665682] Rothfels, Karen, 2019-10-31 [InstanceEdit:9674656] Rothfels, Karen, 2020-01-17 [InstanceEdit:9677119] Rothfels, Karen, 2020-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	EGR1 and NAB co-repressors bind EGR1 gene
output	[Complex:9613178] EGR1 gene:EGR1:NAB1,NAB2 [nucleoplasm] [Homo sapiens]
releaseDate	2020-03-17
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9613204] R-HSA-9613202.2
summation	[Summation:9613201] EGR1 expression is repressed by the recruitment of NAB prote...
(hasEvent)	[Pathway:9031628] NGF-stimulated transcription [Homo sapiens]
[Change default viewing format]

No pathways have been reviewed or authored by EGR1 and NAB co-repressors bind EGR1 gene (9613202)