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Details on Person Expression of ID2 and ID4 is repressed by EGR2:NAB

Class:Id	BlackBoxEvent:9612534
_displayName	Expression of ID2 and ID4 is repressed by EGR2:NAB
_doRelease	TRUE
_timestamp	2020-02-27 16:05:40
authored	[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9612535] Rothfels, Karen, 2018-06-28
edited	[InstanceEdit:9676974] Rothfels, Karen, 2020-02-24
input	[DefinedSet:9612537] ID2, ID4 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9613399] Helix-loop-helix proteins: regulators of transcription in eucaryotic organisms [LiteratureReference:9613409] Id family of helix-loop-helix proteins in cancer [LiteratureReference:9613471] Id proteins: small molecules, mighty regulators [LiteratureReference:9613066] Active gene repression by the Egr2.NAB complex during peripheral nerve myelination [LiteratureReference:9613097] NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex [LiteratureReference:9613444] The nucleosome remodeling and deacetylase chromatin remodeling (NuRD) complex is required for peripheral nerve myelination
modified	[InstanceEdit:9613483] Rothfels, Karen, 2018-07-13 [InstanceEdit:9664638] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665683] Rothfels, Karen, 2019-10-31 [InstanceEdit:9674656] Rothfels, Karen, 2020-01-17 [InstanceEdit:9677119] Rothfels, Karen, 2020-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of ID2 and ID4 is repressed by EGR2:NAB
output	[DefinedSet:9612533] ID2, ID4 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9613476] EGR2:NAB2 and CHD4 bind the ID2 and ID4 promoter regions [Homo sapiens]
regulatedBy	[NegativeRegulation:9613473] Negative regulation by 'ID2,ID4 gene:EGR2:NAB2:CHD4 [nucleoplasm]'
releaseDate	2020-03-17
reviewed	[InstanceEdit:9674653] Aletta, John M, 2020-01-17
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9612540] R-HSA-9612534.2
summation	[Summation:9613467] ID1-4 (Inhibitor of DNA-binding) are members of the helix-lo...
(hasEvent)	[Pathway:9031628] NGF-stimulated transcription [Homo sapiens]
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No pathways have been reviewed or authored by Expression of ID2 and ID4 is repressed by EGR2:NAB (9612534)