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Details on Person NGF- and MAPK-dependent EGR1, EGR2 and EGR4 expression
Class:Id BlackBoxEvent:9612073 _displayName NGF- and MAPK-dependent EGR1, EGR2 and EGR4 expression _doRelease TRUE _timestamp 2020-02-27 16:05:55 authored [InstanceEdit:9658548] Rothfels, Karen, 2019-08-16 compartment [Compartment:7660] nucleoplasm created [InstanceEdit:9612071] Rothfels, Karen, 2018-06-25 edited [InstanceEdit:9676974] Rothfels, Karen, 2020-02-24 input [DefinedSet:9612056] EGR1, EGR2, EGR4 genes [nucleoplasm] [Homo sapiens] isChimeric FALSE literatureReference [LiteratureReference:9612009] Early growth response 1--a transcription factor in the crossfire of signal transduction cascades [LiteratureReference:9612019] Gene regulation in the immediate-early response process [LiteratureReference:9611984] Activation and function of immediate-early genes in the nervous system [LiteratureReference:9612028] Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREB/ATF proteins [LiteratureReference:9612035] The EGR family of transcription-regulatory factors: progress at the interface of molecular and systems neuroscience [LiteratureReference:9611999] Binding and inhibition of the ternary complex factor Elk-4/Sap1 by the adapter protein Dok-4 [LiteratureReference:9612033] Nerve growth factor induces transcription of NGFIA through complex regulatory elements that are also sensitive to serum and phorbol 12-myristate 13-acetate [LiteratureReference:9612004] ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1 [LiteratureReference:9611968] A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor [LiteratureReference:9611971] A zinc finger-encoding gene coregulated with c-fos during growth and differentiation, and after cellular depolarization [LiteratureReference:9031578] Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation [LiteratureReference:9612044] The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family [LiteratureReference:9612022] Identification of NAB1, a repressor of NGFI-A- and Krox20-mediated transcription [LiteratureReference:9612017] Full promoter sequence of human early growth response factor-1 (Egr-1): demonstration of a fifth functional serum response element [LiteratureReference:9612317] Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals [LiteratureReference:9611991] BMP enhances transcriptional responses to NGF during PC12 cell differentiation [LiteratureReference:9612047] The human transcriptional repressor protein NAB1: expression and biological activity modified [InstanceEdit:9612555] Rothfels, Karen, 2018-06-28 [InstanceEdit:9622027] Rothfels, Karen, 2018-09-28 [InstanceEdit:9664638] Rothfels, Karen, 2019-10-25 [InstanceEdit:9665683] Rothfels, Karen, 2019-10-31 [InstanceEdit:9674656] Rothfels, Karen, 2020-01-17 [InstanceEdit:9677119] Rothfels, Karen, 2020-02-27 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 name NGF- and MAPK-dependent EGR1, EGR2 and EGR4 expression output [DefinedSet:9612066] EGR1, EGR2,EGR4 [nucleoplasm] [Homo sapiens] regulatedBy [PositiveGeneExpressionRegulation:9612070] Positive gene expression regulation by 'p-4S, T336 ELK1:SRF:EGR1,EGR2 genes [nucleoplasm]' releaseDate 2020-03-17 reviewed [InstanceEdit:9674653] Aletta, John M, 2020-01-17 reviewStatus [ReviewStatus:9821382] five stars species [Species:48887] Homo sapiens stableIdentifier [StableIdentifier:9612074] R-HSA-9612073.2 summation [Summation:9612072] The Early Growth Response (EGR) gene family includes EGR1-4 ... (hasEvent) [Pathway:9031628] NGF-stimulated transcription [Homo sapiens]
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