Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person UniProt:A0A0P0XII1 CERK1
| Class:Id | ReferenceGeneProduct:9611420 |
|---|---|
| _displayName | UniProt:A0A0P0XII1 CERK1 |
| _timestamp | 2025-08-15 22:15:40 |
| chain | signal peptide:1-18 chain:19-624 |
| checksum | 62635BB84B57C9CE |
| comment | FUNCTION Lysin motif (LysM) receptor kinase required as a cell surface receptor for chitin elicitor (chitooligosaccharides) signaling leading to innate immunity in response to biotic stresses. Involved in the resistance to pathogenic fungi, probably by sensing microbe-associated molecular patterns (MAMP) and pathogen-associated molecular patterns (PAMP) (PubMed:21070404, PubMed:22891159, PubMed:24964058). Involved in the detection of microbial peptidoglycans (PGNs) and mediates PGN response (PubMed:24964058). Plays dual roles in PGN and chitin signaling during innate immunity. Acts as an adapter for LYP4 and LYP6 and mediates signal transduction from the extracellular to intracellular spaces. Participates in the activation of defense genes during response to PGN and chitin (PubMed:25335639). Phosphorylates the downstream partner RLCK185 in response to chitin elicitation (PubMed:23498959).CATALYTIC ACTIVITY L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H(+)CATALYTIC ACTIVITY L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H(+)SUBUNIT Homooligomer. Interacts with CEBIP (PubMed:21070404). Interacts with LYP4 and LYP6 (PubMed:24964058, PubMed:25335639). Interacts with RLCK176 (PubMed:25335639).SUBCELLULAR LOCATION Expressed in seedlings, roots, shoots and stems, and, to a lower extent, in flowers.PTM Autophosphorylated; induced by chitin and derivatives.DISRUPTION PHENOTYPE Suppression of the defense responses induced by chitin oligosaccharides.SIMILARITY Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.SEQUENCE CAUTION Truncated N-terminus.SEQUENCE CAUTION Truncated N-terminus. |
| created | [InstanceEdit:9611567] Naithani, Sushma, 2018-06-18 |
| description | recommendedName: fullName evidence="12"Chitin elicitor receptor kinase 1 shortName evidence="12"OsCERK1 ecNumber evidence="9"2.7.11.1 alternativeName: fullName evidence="13"LysM domain receptor-like kinase 1 shortName evidence="13"LysM RLK1 shortName evidence="13"LysM-containing receptor-like kinase 1 alternativeName: fullName evidence="12"LysM domain receptor-like kinase 9 shortName evidence="12"OsLysM-RLK9 |
| geneName | CERK1 RLK9 Os08g0538300 LOC_Os08g42580 P0665C04.34 P0666G10.101 |
| identifier | A0A0P0XII1 |
| isSequenceChanged | FALSE |
| keyword | 3D-structure ATP-binding Cell membrane Chitin-binding Disulfide bond Glycoprotein Immunity Innate immunity Kinase Membrane Nucleotide-binding Plant defense Receptor Reference proteome Serine/threonine-protein kinase Signal Transferase Transmembrane Transmembrane helix |
| modified | [InstanceEdit:9616384] Weiser, JD [InstanceEdit:9637257] Weiser, JD [InstanceEdit:9676415] Weiser, JD [InstanceEdit:9698430] Weiser, JD [InstanceEdit:9829221] Weiser, Joel [InstanceEdit:9852000] Weiser, Joel, 2023-11-03 [InstanceEdit:9939033] Weiser, Joel, 2025-02-21 [InstanceEdit:9963647] Weiser, Joel, 2025-08-15 |
| name | CERK1 |
| referenceDatabase | [ReferenceDatabase:2] UniProt |
| secondaryIdentifier | CERK1_ORYSJ B7F461 Q0J431 Q6ZD33 |
| sequenceLength | 624 |
| species | [Species:1250427] Oryza sativa subsp. japonica |
| (referenceEntity) | [EntityWithAccessionedSequence:9611466] CERK1 [plasma membrane] [Oryza sativa] [EntityWithAccessionedSequence:9611549] phosphorylated-CERK1 [plasma membrane] [Oryza sativa] |
| [Change default viewing format] | |
No pathways have been reviewed or authored by UniProt:A0A0P0XII1 CERK1 (9611420)
