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Details on Person P2RY12 binds P2RY12 antagonists

Class:Id	Reaction:9611277
_displayName	P2RY12 binds P2RY12 antagonists
_doRelease	TRUE
_timestamp	2021-03-25 11:09:51
authored	[InstanceEdit:9611251] Jassal, Bijay, 2018-06-18
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:9611251] Jassal, Bijay, 2018-06-18
edited	[InstanceEdit:9611251] Jassal, Bijay, 2018-06-18
input	[EntityWithAccessionedSequence:391959] P2RY12 [plasma membrane] [Homo sapiens] [DefinedSet:9611319] P2RY12 antagonists [extracellular region]
isChimeric	FALSE
literatureReference	[LiteratureReference:400628] Identification of the platelet ADP receptor targeted by antithrombotic drugs [LiteratureReference:9611275] Ticagrelor binds to human P2Y(12) independently from ADP but antagonizes ADP-induced receptor signaling and platelet aggregation [LiteratureReference:9611306] Modeling ligand recognition at the P2Y12 receptor in light of X-ray structural information [LiteratureReference:9611263] Effects of P2Y12 receptor antagonists beyond platelet inhibition--comparison of ticagrelor with thienopyridines [LiteratureReference:9611266] Ticagrelor inhibits human platelet aggregation via adenosine in addition to P2Y12 antagonism [LiteratureReference:9611285] Characterization of the adenosine pharmacology of ticagrelor reveals therapeutically relevant inhibition of equilibrative nucleoside transporter 1 [LiteratureReference:9611297] Inverse agonism at the P2Y12 receptor and ENT1 transporter blockade contribute to platelet inhibition by ticagrelor [LiteratureReference:9611282] P2Y12, a new platelet ADP receptor, target of clopidogrel [LiteratureReference:9611254] Ticlopidine. A review of its pharmacology, clinical efficacy and tolerability in the prevention of cerebral ischaemia and stroke [LiteratureReference:9611267] Ticlopidine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in platelet-dependent disease states [LiteratureReference:9611268] Stereoselective inhibition of human platelet aggregation by R-138727, the active metabolite of CS-747 (prasugrel, LY640315), a novel P2Y12 receptor inhibitor [LiteratureReference:9611336] A comparison of cangrelor, prasugrel, ticagrelor, and clopidogrel in patients undergoing percutaneous coronary intervention: A network meta-analysis [LiteratureReference:9611664] Structure and stereochemistry of the active metabolite of clopidogrel [LiteratureReference:9625615] Cangrelor: an emerging therapeutic option for patients with coronary artery disease
modified	[InstanceEdit:9611338] Jassal, Bijay, 2018-06-18 [InstanceEdit:9611663] Jassal, Bijay, 2018-06-19 [InstanceEdit:9611667] Jassal, Bijay, 2018-06-19 [InstanceEdit:9619123] Jassal, Bijay, 2018-09-14 [InstanceEdit:9625621] Jassal, Bijay, 2018-10-22 [InstanceEdit:9724715] Jassal, Bijay, 2021-03-25 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	P2RY12 binds P2RY12 antagonists
output	[Complex:9611315] P2RY12:P2RY12 antagonists [plasma membrane] [Homo sapiens]
releaseDate	2018-12-09
reviewed	[InstanceEdit:9619122] Toomey, John, 2018-09-14
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9611331] R-HSA-9611277.3
summation	[Summation:9611322] P2Y purinoceptor 12 (P2RY12) is found on the surface of bloo...
(hasEvent)	[Pathway:417957] P2Y receptors [Homo sapiens]
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