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Details on Person All GluN2 (GRIN2) family subunits, GluN2A (GRIN2A), GluN2B (...

Class:IdSummation:9610675
_displayNameAll GluN2 (GRIN2) family subunits, GluN2A (GRIN2A), GluN2B (...
_timestamp2019-02-12 17:45:16
created[InstanceEdit:9610663] Orlic-Milacic, Marija, 2018-06-11
literatureReference[LiteratureReference:9610668] PDZ protein interactions underlying NMDA receptor-mediated excitotoxicity and neuroprotection by PSD-95 inhibitors
[LiteratureReference:9610676] Differential interaction of NMDA receptor subtypes with the post-synaptic density-95 family of membrane associated guanylate kinase proteins
[LiteratureReference:9610858] Dynamic and specific interaction between synaptic NR2-NMDA receptor and PDZ proteins
modified[InstanceEdit:9610708] Orlic-Milacic, Marija, 2018-06-11
[InstanceEdit:9610709] Orlic-Milacic, Marija, 2018-06-11
[InstanceEdit:9610710] Orlic-Milacic, Marija, 2018-06-11
[InstanceEdit:9610863] Orlic-Milacic, Marija, 2018-06-12
[InstanceEdit:9611029] Orlic-Milacic, Marija, 2018-06-14
[InstanceEdit:9636357] Orlic-Milacic, Marija, 2019-02-12
textAll GluN2 (GRIN2) family subunits, GluN2A (GRIN2A), GluN2B (GRIN2B), GluN2C (GRIN2C) and GluN2D (GRIN2D), can bind to any of the PSD-95 protein family members DLG1 (SAP-97), DLG2 (PSD-93), DLG3 (SAP-102) and DLG4 (PSD-95). Binding to different PSD-95 family members does not affect transport of GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors to the plasma membrane, but does affect their positioning and retention at the plasma membrane postsynaptic density, as well as their excitability (Cui et al. 2007, Cousins et al. 2008, Bard et al. 2010). DLG4, the most prominent postsynaptic density protein, can also interact directly with GluN1 isoforms that possess the PDZ-binding domain in their C-terminus (Kornau et al. 1995).
(summation)[Reaction:9610653] GluN1:GluN2 (GRIN1:GRIN2) NMDA receptors bind to postsynaptic density proteins [Homo sapiens]
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