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Details on Person p-T,Y MAPK dimers translocate to nucleus

Class:IdBlackBoxEvent:9610166
_displayNamep-T,Y MAPK dimers translocate to nucleus
_doReleaseTRUE
_timestamp2019-08-16 14:45:18
authored[InstanceEdit:9610162] Rothfels, Karen, 2018-06-05
compartment[Compartment:70101] cytosol
[Compartment:7660] nucleoplasm
created[InstanceEdit:9610162] Rothfels, Karen, 2018-06-05
edited[InstanceEdit:9610183] Rothfels, Karen, 2018-06-05
input[DefinedSet:1268261] p-T,Y MAPK dimers [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:9031578] Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation
[LiteratureReference:9610764] Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells
[LiteratureReference:9610094] Transcription factors and effectors that regulate neuronal morphology
[LiteratureReference:5674347] ERK dimers and scaffold proteins: unexpected partners for a forgotten (cytoplasmic) task
[LiteratureReference:5673943] ERK1/2 MAP kinases: structure, function, and regulation
modified[InstanceEdit:9610775] Rothfels, Karen, 2018-06-12
[InstanceEdit:9621981] Rothfels, Karen, 2018-09-28
[InstanceEdit:9658547] Rothfels, Karen, 2019-08-16
[InstanceEdit:9658548] Rothfels, Karen, 2019-08-16
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namep-T,Y MAPK dimers translocate to nucleus
output[DefinedSet:198701] p-T,Y MAPK dimers [nucleoplasm] [Homo sapiens]
precedingEvent
releaseDate2015-06-17
reviewed[InstanceEdit:5690572] Roskoski, Robert Jr, 2015-04-28
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9610167] R-HSA-9610166.2
summation[Summation:9610774] After phosphorylation by MAP2Ks, a proportion of activated M...
(hasEvent)[Pathway:170968] Frs2-mediated activation [Homo sapiens]
(precedingEvent)[Reaction:198731] ERK1/2 activates ELK1 [Homo sapiens]
[Reaction:198746] ERK1/2/5 activate RSK1/2/3 [Homo sapiens]
[Reaction:198756] ERK1/2 phosphorylates MSK1 [Homo sapiens]
[Reaction:199959] ERKs are inactivated by protein phosphatase 2A [Homo sapiens]
[Reaction:203797] ERKs are inactivated by dual-specific phosphatases (DUSPs) [Homo sapiens]
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