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Details on Person GluN1 (GRIN1) forms a di-heterotetramer with GluN2D (GRIN2D)...

Class:IdSummation:9610064
_displayNameGluN1 (GRIN1) forms a di-heterotetramer with GluN2D (GRIN2D)...
_timestamp2019-02-14 17:44:53
created[InstanceEdit:9610066] Orlic-Milacic, Marija, 2018-06-05
literatureReference[LiteratureReference:9610106] Subunit composition of N-methyl-D-aspartate receptors in the central nervous system that contain the NR2D subunit
[LiteratureReference:9609810] NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
[LiteratureReference:9637125] GluN2D-Containing N-methyl-d-Aspartate Receptors Mediate Synaptic Transmission in Hippocampal Interneurons and Regulate Interneuron Activity
[LiteratureReference:9637135] GluN2D-containing NMDA receptors-mediate synaptic currents in hippocampal interneurons and pyramidal cells in juvenile mice
[LiteratureReference:9637143] Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors
[LiteratureReference:9637140] Structural determinants of agonist efficacy at the glutamate binding site of N-methyl-D-aspartate receptors
modified[InstanceEdit:9610111] Orlic-Milacic, Marija, 2018-06-05
[InstanceEdit:9610117] Orlic-Milacic, Marija, 2018-06-05
[InstanceEdit:9610201] Orlic-Milacic, Marija, 2018-06-05
[InstanceEdit:9610246] Orlic-Milacic, Marija, 2018-06-06
[InstanceEdit:9611827] Orlic-Milacic, Marija, 2018-06-20
[InstanceEdit:9636353] Orlic-Milacic, Marija, 2019-02-12
[InstanceEdit:9637137] Orlic-Milacic, Marija, 2019-02-14
[InstanceEdit:9637138] Orlic-Milacic, Marija, 2019-02-14
[InstanceEdit:9637145] Orlic-Milacic, Marija, 2019-02-14
textGluN1 (GRIN1) forms a di-heterotetramer with GluN2D (GRIN2D) in heterologous expression systems, although stoichiometry is unclear in neurons. The tetramer includes two molecules of GluN1 and two molecules of GluN2D (Dunah et al. 1998). GluN2D is expressed in the brain during embryonic development. In adult brain, GluN2D expression is low and mostly restricted to diencephalon and mesencephalon, as well as GABAergic interneurons (von Engelhardt et al. 2015, Perszyk et al. 2016, reviewed by Paoletti et al. 2013). The ligand binding domain of GluN2D interacts with agonists in a similar fashion to other GluN2 subunits (Vance et al. 2011, Hansen et al. 2013).
(summation)[Reaction:9609741] Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2D (GRIN2D) [Homo sapiens]
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