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Details on Person GluN3A (GRIN3A) interacts with GluN1 (GRIN1) to form a di-he...

Class:IdSummation:9610063
_displayNameGluN3A (GRIN3A) interacts with GluN1 (GRIN1) to form a di-he...
_timestamp2019-02-14 21:59:03
created[InstanceEdit:9610066] Orlic-Milacic, Marija, 2018-06-05
literatureReference[LiteratureReference:9610216] Excitatory glycine receptors containing the NR3 family of NMDA receptor subunits
[LiteratureReference:9609810] NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease
[LiteratureReference:9610248] Pharmacological characterization of glycine-activated currents in HEK 293 cells expressing N-methyl-D-aspartate NR1 and NR3 subunits
[LiteratureReference:9610262] Assembly with the NR1 subunit is required for surface expression of NR3A-containing NMDA receptors
[LiteratureReference:9627458] Glutamate receptor ion channels: structure, regulation, and function
[LiteratureReference:9637149] Structure-based discovery of antagonists for GluN3-containing N-methyl-D-aspartate receptors
[LiteratureReference:9637155] Unmasking GluN1/GluN3A excitatory glycine NMDA receptors
[LiteratureReference:9637224] Subunit-specific roles of glycine-binding domains in activation of NR1/NR3 N-methyl-D-aspartate receptors
modified[InstanceEdit:9610227] Orlic-Milacic, Marija, 2018-06-06
[InstanceEdit:9610246] Orlic-Milacic, Marija, 2018-06-06
[InstanceEdit:9610247] Orlic-Milacic, Marija, 2018-06-06
[InstanceEdit:9610252] Orlic-Milacic, Marija, 2018-06-06
[InstanceEdit:9610266] Orlic-Milacic, Marija, 2018-06-06
[InstanceEdit:9636353] Orlic-Milacic, Marija, 2019-02-12
[InstanceEdit:9637151] Orlic-Milacic, Marija, 2019-02-14
[InstanceEdit:9637158] Orlic-Milacic, Marija, 2019-02-14
[InstanceEdit:9637159] Orlic-Milacic, Marija, 2019-02-14
[InstanceEdit:9637226] Orlic-Milacic, Marija, 2019-02-14
textGluN3A (GRIN3A) interacts with GluN1 (GRIN1) to form a di-heteromeric NMDA receptor (Perez-Otano et al. 2001, Chatterton et al. 2002). The tetrameric structure of the GluN1:GluN3A (GRIN1:GRIN3A) di-heteromer is inferred from the tetrameric architecture of all known glutamate receptors (Traynelis et al. 2010). GluN3A expression reaches the highest level in early postnatal period and then declines (reviewed by Paoletti et al. 2013). GluN1:GluN3A di-heteromers can be activated by glycine in Xenopus oocytes (Smothers and Woodward 2007), and the action of glycine can be greatly enhanced by diminishing the ability of GluN1 subunit to interact with glycine (Awobuluyi et al. 2007, Kvist et al. 2013, Grand et al. 2018).
(summation)[Reaction:9609747] Formation of di-heterotetramers of GluN1 (GRIN1) and GluN3A (GRIN3A) [Homo sapiens]
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