Reactome: A Curated Pathway Database
THIS SITE IS USED FOR CURATION AND TESTING
IT IS NOT STABLE, IS LINKED TO AN INCOMPLETE DATA SET, AND IS NOT MONITORED FOR PERFORMANCE. WE STRONGLY RECOMMEND THE USE OF OUR PUBLIC SITE

Query author contributions in Reactome

Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.

If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.

Name Email address

Details on Person GluN1 (GRIN1) forms a tri-heterotetramer with GluN2A (GRIN2A...

Class:IdSummation:9609838
_displayNameGluN1 (GRIN1) forms a tri-heterotetramer with GluN2A (GRIN2A...
_timestamp2019-02-14 18:59:15
created[InstanceEdit:9609839] Orlic-Milacic, Marija, 2018-06-01
literatureReference[LiteratureReference:9609824] Changing subunit composition of heteromeric NMDA receptors during development of rat cortex
[LiteratureReference:9637163] Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation
[LiteratureReference:9636335] Distinct functional and pharmacological properties of Triheteromeric GluN1/GluN2A/GluN2B NMDA receptors
modified[InstanceEdit:9609969] Orlic-Milacic, Marija, 2018-06-04
[InstanceEdit:9610069] Orlic-Milacic, Marija, 2018-06-05
[InstanceEdit:9610246] Orlic-Milacic, Marija, 2018-06-06
[InstanceEdit:9610313] Orlic-Milacic, Marija, 2018-06-06
[InstanceEdit:9636354] Orlic-Milacic, Marija, 2019-02-12
[InstanceEdit:9637164] Orlic-Milacic, Marija, 2019-02-14
[InstanceEdit:9637165] Orlic-Milacic, Marija, 2019-02-14
[InstanceEdit:9637166] Orlic-Milacic, Marija, 2019-02-14
textGluN1 (GRIN1) forms a tri-heterotetramer with GluN2A (GRIN2A) and GluN2B (GRIN2B). The tetramer includes two molecules of GluN1, one molecule of GluN2A and one molecule of GluN2B (Sheng et al. 1994). The tetrameric structure of the GluN1:GluN2A:GluN2B (GRIN1:GRIN2A:GRIN2B) triheteromeric NMDA receptor was demonstrated on the cryo-EM structure of the Xenopus orthologue (Lu et al. 2017). The majority of native NMDA receptors in adult forebrain are GluN1:GluN2A:GluN2B tri-heteromers, and their pharmacological properties are distinct from the properties of GluN1:GluN2A and GluN1:GluN2B di-heteromers (Hansen et al. 2014).
(summation)[Reaction:9609746] Formation of tri-heterotetramers of GluN1 (GRIN1), GluN2A (GRIN2A) and GluN2B (GRIN2B) [Homo sapiens]
[Change default viewing format]
No pathways have been reviewed or authored by GluN1 (GRIN1) forms a tri-heterotetramer with GluN2A (GRIN2A... (9609838)
Follow Reactome