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Details on Person GluN2A (GRIN2A) forms a di-heterotetramer with GluN1 (GRIN1)...

Class:IdSummation:9609833
_displayNameGluN2A (GRIN2A) forms a di-heterotetramer with GluN1 (GRIN1)...
_timestamp2019-02-14 21:47:48
created[InstanceEdit:9609832] Orlic-Milacic, Marija, 2018-06-01
literatureReference[LiteratureReference:9609824] Changing subunit composition of heteromeric NMDA receptors during development of rat cortex
[LiteratureReference:9609978] Heteromeric NMDA receptors: molecular and functional distinction of subtypes
[LiteratureReference:9610058] Subunit arrangement and function in NMDA receptors
[LiteratureReference:9637109] Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
modified[InstanceEdit:9609853] Orlic-Milacic, Marija, 2018-06-01
[InstanceEdit:9609960] Orlic-Milacic, Marija, 2018-06-04
[InstanceEdit:9609970] Orlic-Milacic, Marija, 2018-06-04
[InstanceEdit:9609984] Orlic-Milacic, Marija, 2018-06-04
[InstanceEdit:9610060] Orlic-Milacic, Marija, 2018-06-05
[InstanceEdit:9636353] Orlic-Milacic, Marija, 2019-02-12
[InstanceEdit:9637110] Orlic-Milacic, Marija, 2019-02-14
[InstanceEdit:9637219] Orlic-Milacic, Marija, 2019-02-14
textGluN2A (GRIN2A) forms a di-heterotetramer with GluN1 (GRIN1). Based on the crystal structure of the rat GluN1:GluN2A (Grin1:Grin2a) NMDA receptor (Furukawa et al. 2005) and the Cryo-EM structure of the human GluN1:GluN2A (GRIN1:GRIN2A) NMDA receptor (Zhang et al. 2018), the tetramer includes 2 molecules of GluN1 and two molecules of GluN2A. GluN2A expression starts postnatally and GluN2A is highly expressed in adult brain (Monyer et al. 1992, Sheng et al. 1994).
(summation)[Reaction:9609742] Formation of di-heterotetramers of GluN1 (GRIN1) and GluN2A (GRIN2A) [Homo sapiens]
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