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Details on Person The perilipin 1 (PLIN1) gene is transcribed to yield mRNA an...
| Class:Id | Summation:9608049 |
|---|---|
| _displayName | The perilipin 1 (PLIN1) gene is transcribed to yield mRNA an... |
| _timestamp | 2019-08-13 05:31:23 |
| created | [InstanceEdit:9608047] Shamovsky, Veronica, 2018-05-08 |
| literatureReference | [LiteratureReference:9608024] Liver X receptor (LXR) regulates human adipocyte lipolysis |
| modified | [InstanceEdit:9634037] Shamovsky, Veronica, 2019-01-03 [InstanceEdit:9658380] Shamovsky, Veronica, 2019-08-13 |
| text | The perilipin 1 (PLIN1) gene is transcribed to yield mRNA and the mRNA is translated to yield protein. Liver X receptors (LXRα, NR1H2,3) up-regulate basal human adipocyte lipolysis partially through NR1H2,3 binding to the PLIN1 promoter and down-regulation of PLIN1 expression (Stenson BM et al. 2011). By selective knockdown of either NR1H2 or NR1H3, NR1H3 was found to be the major isoform mediating the lipolysis-related effects of NR1H2,3. The Reactome event of NR1H2,3-regulated expression of PLIN1 is inferred from the analogous event regulated by a synthetic NR1H2,3 agonist GW3965 (Stenson BM et al. 2011). |
| (summation) | [BlackBoxEvent:9608048] Expression of PLIN1 regulated by NR1H2 or NR1H3 [Homo sapiens] |
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No pathways have been reviewed or authored by The perilipin 1 (PLIN1) gene is transcribed to yield mRNA an... (9608049)
