Query author contributions in Reactome
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Details on Person Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a me...
| Class:Id | Summation:9607302 |
|---|---|
| _displayName | Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a me... |
| _timestamp | 2019-01-16 13:57:13 |
| created | [InstanceEdit:9607299] Varusai, Thawfeek, 2018-05-02 |
| modified | [InstanceEdit:9607308] Varusai, Thawfeek, 2018-05-02 [InstanceEdit:9634820] Varusai, Thawfeek, 2019-01-16 |
| text | Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a member of the class III tyrosine kinase receptor family. Ligand binding induces conformational changes in the FLT3 receptor, which facilitates its dimerization and autophosphorylation. Once fully active, FLT3 receptors can associate with growth factor receptor-bound protein 2 (GRB2), which then recruits Son of sevenless homolog 1 (SOS1). Consequently, this triggers the activation of the ERK signaling cascade (Li et al. 1993). |
| (summation) | [Reaction:9607301] Active FLT3:GRB2 binds SOS1 [Homo sapiens] |
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No pathways have been reviewed or authored by Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a me... (9607302)
