Query author contributions in Reactome
Reactome depends on collaboration between our curation team and outside experts to assemble and peer-review its pathway modules. The integration of ORCID within Reactome enables us to meet a key challenge with authoring, curating and reviewing biological information by incentivizing and crediting the external experts that contribute their expertise and time to the Reactome curation process. More information is available at ORCID and Reactome.
If you have an ORCID ID that is not listed on this page, please forward this information to us and we will update your Reactome pathway records.
Details on Person FMS-like tyrosine kinase (Flt3) (also known as Flk2 (fetal l...
| Class:Id | Summation:9607231 |
|---|---|
| _displayName | FMS-like tyrosine kinase (Flt3) (also known as Flk2 (fetal l... |
| _timestamp | 2018-05-01 12:28:42 |
| created | [InstanceEdit:9607232] Varusai, Thawfeek, 2018-05-01 |
| text | FMS-like tyrosine kinase (Flt3) (also known as Flk2 (fetal liver tyrosine kinase 2), Stk-1 (stem cell tyrosine kinase 1) or CD135) is a tyrosine kinase receptor. Ligand binding induces conformational changes in Flt3 receptor, which facilitates its dimerization and autophosphorylation. Once fully active, Flt3 receptors can associate with Growth factor receptor-bound protein 2 (Grb2), which then recruits Grb2-associated-binding protein 2 (Gab2). Consequently, Gab2 is phosphorylated and recruits Phosphatidylinositol 3-kinase regulatory subunit alpha (Pik3r1) (Zhang S et al. 2000, Masson K et al. 2009). This event is represented as a black box since the precise association mechanism of Gab2 and PIK3R1 is unclear. |
| [Change default viewing format] | |
No pathways have been reviewed or authored by FMS-like tyrosine kinase (Flt3) (also known as Flk2 (fetal l... (9607231)
