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Details on Person Activated BTK (BTK phosphorylated on tyrosine-551 and tyrosi...
| Class:Id | Summation:9607057 |
|---|---|
| _displayName | Activated BTK (BTK phosphorylated on tyrosine-551 and tyrosi... |
| _timestamp | 2018-04-30 08:08:33 |
| created | [InstanceEdit:9607054] May, Bruce, 2018-04-30 |
| text | Activated BTK (BTK phosphorylated on tyrosine-551 and tyrosine-223) bound to phosphorylated BLNK phosphorylates phospholipase gamma-2 (PKCG2) on tyrosines 753, 759, and 1217 (Rodriguez et al. 2001 and inferred from the rat homolog) thereby activating PLCG2 to hydrolyze phosphatidylinositol 4,5-bisphosphate, yielding the second messengers diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) (Carter et al. 1991, Roifman and Wang 1992, Kim et al. 2004, Sekiya et al. 2004). PLCG2 also binds phosphoinositol 3,4,5-trisphosphate (PIP3) produced by PI3K at the plasma membrane. |
| (summation) | [Reaction:9606162] Phosphorylated BTK phosphorylates PLCG2 [Homo sapiens] |
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No pathways have been reviewed or authored by Activated BTK (BTK phosphorylated on tyrosine-551 and tyrosi... (9607057)
