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Details on Person p-CD19:VAV binds PI3K and GRB2

Class:IdReaction:9606887
_displayNamep-CD19:VAV binds PI3K and GRB2
_doReleaseTRUE
_timestamp2018-07-18 02:14:32
authored[InstanceEdit:9606896] May, Bruce, 2018-04-22
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9606882] May, Bruce, 2018-04-26
edited[InstanceEdit:9606896] May, Bruce, 2018-04-22
input[Complex:9606889] p-CD19:VAV1 [plasma membrane] [Homo sapiens]
[Complex:1806213] PIK3CD:PIK3R1 [cytosol] [Homo sapiens]
[EntityWithAccessionedSequence:74686] GRB2-1 [cytosol] [Homo sapiens]
isChimericFALSE
literatureReference[LiteratureReference:2076214] CD19 is a substrate of the antigen receptor-associated protein tyrosine kinase in human B cells
[LiteratureReference:2076262] Tyrosine phosphorylation of CD19 in pre-B and mature B cells
[LiteratureReference:2076227] Signal transduction through the CD19 receptor during discrete developmental stages of human B-cell ontogeny
[LiteratureReference:2076242] Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors
[LiteratureReference:2076271] Binding of cytoplasmic proteins to the CD19 intracellular domain is high affinity, competitive, and multimeric
[LiteratureReference:2076268] Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines
modified[InstanceEdit:9607054] May, Bruce, 2018-04-30
[InstanceEdit:9613696] May, Bruce, 2018-07-18
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
namep-CD19:VAV binds PI3K and GRB2
output[Complex:2076233] CD19 Signalosome [plasma membrane] [Homo sapiens]
precedingEvent
releaseDate2018-09-12
reviewed[InstanceEdit:9613695] Wienands, J, 2018-07-18
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9606904] R-HSA-9606887.2
summation[Summation:9607055] Phosphorylated CD19 binds PI3K (Roifman and Ke 1993, Chalupn...
(hasEvent)[Pathway:983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers [Homo sapiens]
(precedingEvent)[Reaction:2076220] CD19 Signalosome phosphorylates PI(4,5)P2 forming PI(3,4,5)P3 [Homo sapiens]
(replacementInstances)[_Deleted:9613688] Deletion of instance: 983704
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