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Details on Person Active FLT3:GRB2:p-Y-GAB2 binds PTPN11

Class:Id	BlackBoxEvent:9606784
_displayName	Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
_doRelease	TRUE
_timestamp	2019-05-21 08:35:03
authored	[InstanceEdit:9634693] Varusai, Thawfeek, 2019-01-14
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9606781] Varusai, Thawfeek, 2018-04-25
edited	[InstanceEdit:9634693] Varusai, Thawfeek, 2019-01-14
inferredFrom	[BlackBoxEvent:9606789] Active Flt3:Grb2:p-Y-Gab2 binds Ptpn11 [Mus musculus]
input	[Complex:9606627] Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:162563] PTPN11 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:6786770] Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase [LiteratureReference:9606785] Phosphorylation of Grb2-associated binder 2 on serine 623 by ERK MAPK regulates its association with the phosphatase SHP-2 and decreases STAT5 activation
modified	[InstanceEdit:9606795] Varusai, Thawfeek, 2018-04-25 [InstanceEdit:9607241] Varusai, Thawfeek, 2018-05-01 [InstanceEdit:9607299] Varusai, Thawfeek, 2018-05-02 [InstanceEdit:9634820] Varusai, Thawfeek, 2019-01-16 [InstanceEdit:9645140] Varusai, Thawfeek, 2019-05-04 [InstanceEdit:9646277] Varusai, Thawfeek, 2019-05-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Active FLT3:GRB2:p-Y-GAB2 binds PTPN11
output	[Complex:9606788] Active FLT3:GRB2:p-Y-GAB2:PTPN11 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9606622] GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated [Homo sapiens] [Reaction:9606624] Active FLT3:GRB2 binds GAB2 [Homo sapiens]
releaseDate	2019-06-12
reviewed	[InstanceEdit:9645124] Traer, Elie, 2019-05-03 [InstanceEdit:9646275] Joshi, Sunil, 2019-05-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9606794] R-HSA-9606784.3
summation	[Summation:9606782] Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a me...
(hasEvent)	[Pathway:9607240] FLT3 Signaling [Homo sapiens]
(normalReaction)	[Reaction:9698008] FLT3 mutants:GRB2:p-Y-GAB2 binds PTPN11 [Homo sapiens]
(precedingEvent)	[Pathway:5673001] RAF/MAP kinase cascade [Homo sapiens] [Reaction:9645126] Activators bind STAT5 [Homo sapiens] [Pathway:9645135] STAT5 Activation [Homo sapiens]
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No pathways have been reviewed or authored by Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 (9606784)