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Details on Person GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated

Class:Id	BlackBoxEvent:9606622
_displayName	GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated
_doRelease	TRUE
_timestamp	2019-05-21 08:35:20
authored	[InstanceEdit:9634693] Varusai, Thawfeek, 2019-01-14
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9606626] Varusai, Thawfeek, 2018-04-24
edited	[InstanceEdit:9634693] Varusai, Thawfeek, 2019-01-14
inferredFrom	[BlackBoxEvent:9606621] Gab2 in Active Flt3:Grb2:Gab2 is phosphorylated [Mus musculus]
input	[Complex:9606619] Active FLT3:GRB2:GAB2 [plasma membrane] [Homo sapiens] [SimpleEntity:113592] ATP [cytosol]
isChimeric	FALSE
literatureReference	[LiteratureReference:6786770] Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase [LiteratureReference:9604764] A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival [LiteratureReference:9604770] Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3
modified	[InstanceEdit:9606641] Varusai, Thawfeek, 2018-04-24 [InstanceEdit:9607241] Varusai, Thawfeek, 2018-05-01 [InstanceEdit:9607299] Varusai, Thawfeek, 2018-05-02 [InstanceEdit:9634820] Varusai, Thawfeek, 2019-01-16 [InstanceEdit:9645140] Varusai, Thawfeek, 2019-05-04 [InstanceEdit:9646277] Varusai, Thawfeek, 2019-05-21 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated
output	[Complex:9606627] Active FLT3:GRB2:p-Y-GAB2 [plasma membrane] [Homo sapiens] [SimpleEntity:29370] ADP [cytosol]
precedingEvent	[Reaction:9606624] Active FLT3:GRB2 binds GAB2 [Homo sapiens] [Reaction:9604738] Active FLT3 dimer binds GRB2 [Homo sapiens]
releaseDate	2019-06-12
reviewed	[InstanceEdit:9645124] Traer, Elie, 2019-05-03 [InstanceEdit:9646275] Joshi, Sunil, 2019-05-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9606636] R-HSA-9606622.3
summation	[Summation:9606630] Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a me...
(hasEvent)	[Pathway:9607240] FLT3 Signaling [Homo sapiens]
(normalReaction)	[Reaction:9698003] FLT3 mutants phosphorylate GAB2 [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9606784] Active FLT3:GRB2:p-Y-GAB2 binds PTPN11 [Homo sapiens] [Reaction:9607224] Active FLT3:GRB2:p-Y-GAB2 binds PIK3R1 [Homo sapiens]
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No pathways have been reviewed or authored by GAB2 in Active FLT3:GRB2:GAB2 is phosphorylated (9606622)