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Details on Person Defective Mutyh mutants do not cleave adenine mispaired with 8-oxoguanine

Class:Id	FailedReaction:9606338
_displayName	Defective Mutyh mutants do not cleave adenine mispaired with 8-oxoguanine
_doRelease	TRUE
_timestamp	2019-02-11 15:37:34
authored	[InstanceEdit:9608305] Orlic-Milacic, Marija, 2018-05-11
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9606339] Orlic-Milacic, Marija, 2018-04-20
disease	[Disease:1500689] cancer
edited	[InstanceEdit:9612703] Orlic-Milacic, Marija, 2018-06-29
entityFunctionalStatus	[EntityFunctionalStatus:9606342] loss_of_function of Mutyh G257E,Mutyh A341V:(OGUA:Ade)-dsDNA [nucleoplasm]
input	[Complex:9606341] Mutyh G257E,Mutyh A341V:(OGUA:Ade)-dsDNA [nucleoplasm] [Mus musculus]
isChimeric	TRUE
literatureReference	[LiteratureReference:9606302] Genomic and functional analyses of MUTYH in Japanese patients with adenomatous polyposis
modified	[InstanceEdit:9612702] Orlic-Milacic, Marija, 2018-06-29 [InstanceEdit:9612704] Orlic-Milacic, Marija, 2018-06-29 [InstanceEdit:9615998] Orlic-Milacic, Marija, 2018-08-09 [InstanceEdit:9616932] Orlic-Milacic, Marija, 2018-08-15 [InstanceEdit:9616933] Orlic-Milacic, Marija, 2018-08-15 [InstanceEdit:9628565] Orlic-Milacic, Marija, 2018-11-09 [InstanceEdit:9628976] Matthews, Lisa, 2018-11-14 [InstanceEdit:9630110] Orlic-Milacic, Marija, 2018-11-28 [InstanceEdit:9635968] Orlic-Milacic, Marija, 2019-02-11 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Defective Mutyh mutants do not cleave adenine mispaired with 8-oxoguanine
normalReaction	[Reaction:9635966] Mutyh cleaves adenine mispaired with 8-oxoguanine [Mus musculus]
releaseDate	2018-09-12
reviewed	[InstanceEdit:9612701] Nakabeppu, Yusaku, 2018-06-28
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48892] Mus musculus [Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9606344] R-NUL-9606338.4
summation	[Summation:9606340] Mutant variants of mouse Mutyh, Mutyh G257E and Mutyh A341V ...
(inferredFrom)	[FailedReaction:9605313] Defective MUTYH mutants do not cleave adenine mispaired with 8-oxoguanine [Homo sapiens]
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