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Details on Person Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1

Class:Id	Reaction:9606151
_displayName	Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
_doRelease	TRUE
_timestamp	2018-07-18 02:14:27
authored	[InstanceEdit:9606150] May, Bruce, 2018-04-14
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9606166] May, Bruce, 2018-04-19
edited	[InstanceEdit:9606150] May, Bruce, 2018-04-14
input	[Complex:983687] Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:197948] BTK [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:197954] NCK1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:195066] VAV1 [cytosol] [Homo sapiens] [EntityWithAccessionedSequence:984806] PLCG2 [cytosol] [Homo sapiens] [SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane] [SimpleEntity:179838] PI(3,4,5)P3 [plasma membrane]
isChimeric	FALSE
literatureReference	[LiteratureReference:1169540] BLNK mediates Syk-dependent Btk activation [LiteratureReference:983502] BLNK: a central linker protein in B cell activation [LiteratureReference:983470] BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins [LiteratureReference:2076210] SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation [LiteratureReference:9606867] Identification of the SH2 domain binding protein of Bruton's tyrosine kinase as BLNK--functional significance of Btk-SH2 domain in B-cell antigen receptor-coupled calcium signaling [LiteratureReference:2076207] The B-cell antigen receptor signals through a preformed transducer module of SLP65 and CIN85 [LiteratureReference:9613685] Interaction of SLP adaptors with the SH2 domain of Tec family kinases
modified	[InstanceEdit:9606914] May, Bruce, 2018-04-26 [InstanceEdit:9608060] May, Bruce, 2018-05-09 [InstanceEdit:9609854] May, Bruce, 2018-06-02 [InstanceEdit:9613687] May, Bruce, 2018-07-18 [InstanceEdit:9613696] May, Bruce, 2018-07-18 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1
output	[Complex:9606167] Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1:BTK:NCK1:VAV1:PLCG2 [plasma membrane] [Homo sapiens]
precedingEvent	[Reaction:983703] p-6Y-SYK phosphorylates BLNK (SLP65) [Homo sapiens] [Reaction:983707] SYK autophosphorylates at the activated BCR [Homo sapiens]
releaseDate	2018-09-12
reviewed	[InstanceEdit:9613695] Wienands, J, 2018-07-18
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9606171] R-HSA-9606151.2
summation	[Summation:9606897] Phosphorylated BLNK (also called BASH or SLP-65) at the plas...
(hasEvent)	[Pathway:983695] Antigen activates B Cell Receptor (BCR) leading to generation of second messengers [Homo sapiens]
(precedingEvent)	[BlackBoxEvent:9606163] p-SYK and LYN phosphorylate BTK [Homo sapiens]
(replacementInstances)	[_Deleted:9613688] Deletion of instance: 983704
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No pathways have been reviewed or authored by Phosphorylated BLNK (SLP65, in Antigen:p-BCR:p-SYK:p-BLNK:CIN85:GRB2:SOS1) binds BTK, PLCG2, VAV1, NCK1 (9606151)