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Details on Person Ligand rapidly induces translocation of glucocorticoid (GR o...
| Class:Id | Summation:9605744 |
|---|---|
| _displayName | Ligand rapidly induces translocation of glucocorticoid (GR o... |
| _timestamp | 2018-04-17 20:49:07 |
| created | [InstanceEdit:9605743] Shamovsky, Veronica, 2018-04-17 |
| literatureReference | [LiteratureReference:8944764] FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells [LiteratureReference:8944763] The hsp90-FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events [LiteratureReference:9035349] Role of molecular chaperones and TPR-domain proteins in the cytoplasmic transport of steroid receptors and their passage through the nuclear pore [LiteratureReference:8944783] Differential recruitment of tetratricorpeptide repeat domain immunophilins to the mineralocorticoid receptor influences both heat-shock protein 90-dependent retrotransport and hormone-dependent transcriptional activity |
| text | Ligand rapidly induces translocation of glucocorticoid (GR or NR3C1) into the nucleus. The Reactome event shows the microtubule-associated nuclear translocation of NR3C1 (GR) through the recruitment of the large immunophilin FKBP52 (FKBP4) to the chaperone HSP90 complex (Galigniana et al. 2010a; Galigniana et al. 2010b). FKBP52 links glucocorticoid receptor (GR):HSP90 complex to dynein/dynactin motors favoring transport of the cytoplasmic receptor to the nucleus (Wochnik et al. 2005; Gallo et al. 2007). In the absence of the HSP90:FKBP52 complex, NR3C1 dissociates from dynein and is unable to efficiently translocate into the nucleus. By contrast, FKBP51, which does not bind dynein and negatively regulates NR3C1 action, dissociates from the NR3C1 upon ligand binding so as to permit the recruitment of FKBP52 (Wochnik et al. 2005). A similar differential regulation of dynein interaction by FKBP51 and FKBP52 has also been demonstrated for the NR3C2 (MR) (Galigniana et al. 2010a,b; Gallo et al. 2007a). |
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