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Details on Person The alpha-2,3-sialyltransferases ST3GAL3,4 and 6 (Kitagawa &...

Class:IdSummation:9605645
_displayNameThe alpha-2,3-sialyltransferases ST3GAL3,4 and 6 (Kitagawa &...
_timestamp2018-04-16 14:44:32
created[InstanceEdit:9605648] Jassal, Bijay, 2018-04-16
literatureReference[LiteratureReference:9605676] The sialyltransferase ST3GAL6 influences homing and survival in multiple myeloma
modified[InstanceEdit:9605659] Jassal, Bijay, 2018-04-16
textThe alpha-2,3-sialyltransferases ST3GAL3,4 and 6 (Kitagawa & Paulson 1993, Okajima et al. 1999, Kitagawa & Paulson 1994) located on the Golgi membrane, mediate the transfer of sialic acid (Neu5Ac, N-acetylneuraminic acid) in an α2,3 linkage to the terminal galactose of Gal-beta-1,4-GlcNAc- sequences found on glycoproteins and glycolipids to form Type 2 monosialylgalactosylgloboside (Type 2 MSGG).

Increased sialylation has been associated with malignant transformation and metastasis. ST3GAL6 is highly expressed in patients with multiple myeloma (MM). Knockdown of ST3GAL6 has been shown to prolong survival in mice (Glavey et al. 2014).
(summation)[Reaction:9605600] ST3GAL3,4,6 transfer Neu5Ac to Type 2 chain to form Type 2 MSGG [Homo sapiens]
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