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Details on Person NOTCH4 intracellular domain fragment (NICD4) binds phosphory...
| Class:Id | Summation:9605415 |
|---|---|
| _displayName | NOTCH4 intracellular domain fragment (NICD4) binds phosphory... |
| _timestamp | 2018-04-11 16:45:42 |
| created | [InstanceEdit:9605413] Orlic-Milacic, Marija, 2018-04-11 |
| literatureReference | [LiteratureReference:9605427] Notch4 intracellular domain binding to Smad3 and inhibition of the TGF-beta signaling [LiteratureReference:9605437] Notch4-dependent antagonism of canonical TGF-β1 signaling defines unique temporal fluctuations of SMAD3 activity in sheared proximal tubular epithelial cells |
| modified | [InstanceEdit:9605424] Orlic-Milacic, Marija, 2018-04-11 [InstanceEdit:9605439] Orlic-Milacic, Marija, 2018-04-11 [InstanceEdit:9605471] Orlic-Milacic, Marija, 2018-04-11 |
| text | NOTCH4 intracellular domain fragment (NICD4) binds phosphorylated SMAD3 upon activation of TGF-beta signaling. (Sun et al. 2005, Grabias and Konstantopoulos 2013). NICD4 may also bind SMAD2 and SMAD4 (Sun et al. 2005). NICD4 promotes ubiquitination and proteasome-mediated degradation of SMAD3 through and unknown mechanism (Grabias and Konstantopoulos 2013) and inhibits transcription mediated by the heterotrimer of SMAD3, SMAD2 and SMAD4, thus negatively regulating TGF-beta signaling (Sun et al. 2005, Grabias and Konstantopoulos 2013). |
| (summation) | [Reaction:9605414] NOTCH4 binds SMAD3 [Homo sapiens] |
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No pathways have been reviewed or authored by NOTCH4 intracellular domain fragment (NICD4) binds phosphory... (9605415)
