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Details on Person The liver X receptor alpha (LXRα or NR1H3) mRNA is translate...

Class:IdSummation:9605059
_displayNameThe liver X receptor alpha (LXRα or NR1H3) mRNA is translate...
_timestamp2019-08-13 05:31:10
created[InstanceEdit:9605053] Shamovsky, Veronica, 2018-04-06
literatureReference[LiteratureReference:9038557] MicroRNA hsa-miR-613 targets the human LXRα gene and mediates a feedback loop of LXRα autoregulation
[LiteratureReference:9631344] MicroRNA-1 and microRNA-206 suppress LXRα-induced lipogenesis in hepatocytes
[LiteratureReference:9631347] miR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages
modified[InstanceEdit:9618417] Shamovsky, Veronica, 2018-09-06
[InstanceEdit:9621101] Shamovsky, Veronica, 2018-09-26
[InstanceEdit:9631353] Shamovsky, Veronica, 2018-12-06
[InstanceEdit:9634037] Shamovsky, Veronica, 2019-01-03
[InstanceEdit:9658380] Shamovsky, Veronica, 2019-08-13
textThe liver X receptor alpha (LXRα or NR1H3) mRNA is translated to yield NR1H3 protein. MicroRNAs miR-1, miR-206 and miR-613 have been identified as negative regulators of NR1H3 expression and lipogenesis in the liver (Zhong D et al. 2013; Ou Z et al. 2011). Interestingly, miR-206 also regulates NR1H3 in macrophages but in an opposing manner relative to liver (Vinod M et al. 2014). Stably overexpressing miR-206 in THP-1 human macrophages revealed an up-regulation of NR1H3 and miR-206 knockdown led to a down-regulation of NR1H3 and its target genes (Vinod M et al. 2014).
(summation)[BlackBoxEvent:9605052] NR1H3 mRNA is translated [Homo sapiens]
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