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Details on Person Expression of SREBF1 (SREBP1) regulated by NR1H2 or NR1H3

Class:Id	BlackBoxEvent:9605056
_displayName	Expression of SREBF1 (SREBP1) regulated by NR1H2 or NR1H3
_doRelease	TRUE
_timestamp	2019-08-12 15:22:31
authored	[InstanceEdit:9035107] Shamovsky, Veronica, 2018-01-18
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:7660] nucleoplasm
created	[InstanceEdit:9605053] Shamovsky, Veronica, 2018-04-06
edited	[InstanceEdit:9657765] Shamovsky, Veronica, 2019-08-09
input	[EntityWithAccessionedSequence:5641206] SREBF1 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1368918] SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene [LiteratureReference:9028536] The nuclear receptor cofactor, receptor-interacting protein 140, is required for the regulation of hepatic lipid and glucose metabolism by liver X receptor
modified	[InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9632482] Shamovsky, Veronica, 2018-12-18 [InstanceEdit:9632753] Shamovsky, Veronica, 2018-12-21 [InstanceEdit:9634037] Shamovsky, Veronica, 2019-01-03 [InstanceEdit:9637777] Shamovsky, Veronica, 2019-02-19 [InstanceEdit:9641190] Wu, G, 2019-04-04 [InstanceEdit:9657834] Shamovsky, Veronica, 2019-08-09 [InstanceEdit:9658282] Shamovsky, Veronica, 2019-08-12 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of SREBF1 (SREBP1) regulated by NR1H2 or NR1H3
output	[EntityWithAccessionedSequence:1655761] SREBF1-3 [endoplasmic reticulum membrane] [Homo sapiens]
precedingEvent	[Reaction:9028525] NR1H2 or NR1H3, NRIP1 bind the SREBF1 gene [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9035457] Positive gene expression regulation by 'NRIP1:NR1H2,3:RXR:NR1H2,3 ligand:SREBF1 gene [nucleoplasm]'
regulationReference	[RegulationReference:9642420] Positive gene expression regulation by 'NRIP1:NR1H2,3:RXR:NR1H2,3 ligand:SREBF1 gene [nucleoplasm]' The nuclear receptor cofactor, receptor-interacting protein 140, is required for the regulation of hepatic lipid and glucose metabolism by liver X receptor
releaseDate	2019-09-10
reviewed	[InstanceEdit:9633727] D'Eustachio, Peter, 2018-12-29 [InstanceEdit:9657850] Cummins, Carolyn L, Repa, Joyce J, 2019-08-09
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9605071] R-HSA-9605056.2
summation	[Summation:9605066] The sterol regulatory element-binding protein 1 (SREBP1) is ...
(hasEvent)	[Pathway:9029558] NR1H2 & NR1H3 regulate gene expression linked to lipogenesis [Homo sapiens]
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No pathways have been reviewed or authored by Expression of SREBF1 (SREBP1) regulated by NR1H2 or NR1H3 (9605056)