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Details on Person In the nucleus, NOTCH4 intracellular domain fragment (NICD4)...
| Class:Id | Summation:9605036 |
|---|---|
| _displayName | In the nucleus, NOTCH4 intracellular domain fragment (NICD4)... |
| _timestamp | 2018-04-11 16:38:04 |
| created | [InstanceEdit:9605035] Orlic-Milacic, Marija, 2018-04-06 |
| modified | [InstanceEdit:9605453] Orlic-Milacic, Marija, 2018-04-11 [InstanceEdit:9605467] Orlic-Milacic, Marija, 2018-04-11 |
| text | In the nucleus, NOTCH4 intracellular domain fragment (NICD4) binds transcription factors RBPJ (CSL) and mastermind family members (MAML1, MAML2 or MAML3) to form the NOTCH4 co-activator complex (Lin et al. 2002). The NOTCH4 coactivator complex stimulates transcription of well-established NOTCH targets HES1, HES5, HEY1 and HEY2 in a cellular context-dependent manner (Lin et al. 2002, Raafat et al.2004, Tsunematsu et al. 2004, Bargo et al. 2010). NOTCH4 also stimulates transcription of the FLT4 (VEGFR3) gene, encoding vascular endothelial growth factor receptor-3 (Shawber et al. 2007) and ACTA2 gene, encoding smooth muscle alpha actin (Tang et al. 2008). NICD4 inhibits TGF-beta-induced SMAD-mediated transcription via binding of NICD4 to TGF-beta activated SMAD3 (Sun et al. 2005, Grabias and Konstantopoulos 2013). |
| (summation) | [Pathway:9013695] NOTCH4 Intracellular Domain Regulates Transcription [Homo sapiens] |
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No pathways have been reviewed or authored by In the nucleus, NOTCH4 intracellular domain fragment (NICD4)... (9605036)
