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Details on Person Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a me...
| Class:Id | Summation:9604977 |
|---|---|
| _displayName | Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a me... |
| _timestamp | 2019-06-14 10:15:38 |
| created | [InstanceEdit:9604971] Varusai, Thawfeek, 2018-04-06 |
| modified | [InstanceEdit:9604991] Varusai, Thawfeek, 2018-04-06 [InstanceEdit:9634820] Varusai, Thawfeek, 2019-01-16 [InstanceEdit:9645140] Varusai, Thawfeek, 2019-05-04 [InstanceEdit:9649422] Varusai, Thawfeek, 2019-06-14 |
| text | Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a member of the class III tyrosine kinase receptor family. Ligand binding induces conformational changes in the FLT3 receptor, which facilitates its dimerization and autophosphorylation. Once fully active, tyrosine-protein phosphatase non-receptor type 11 (PTPN11) has been reported to directly bind to the Y599 site of Flt3 receptors thereby facilitating downstream regulation of effectors (Heiss et al. 2006, Nabinger et al. 2013). Experiments confirming this event were performed in mouse cells. Interaction of FLT3 with PTPN11 is known to trigger STAT5 activation in various pathological conditions (Mizuki M et al. 2000, Rocnik JL et al. 2006). |
| (summation) | [Reaction:9604969] Active FLT3 binds PTPN11 [Homo sapiens] |
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No pathways have been reviewed or authored by Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a me... (9604977)
