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Details on Person Active FLT3 binds PTPN11

Class:Id	Reaction:9604969
_displayName	Active FLT3 binds PTPN11
_doRelease	TRUE
_timestamp	2019-06-14 10:15:35
authored	[InstanceEdit:9634693] Varusai, Thawfeek, 2019-01-14
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9604971] Varusai, Thawfeek, 2018-04-06
edited	[InstanceEdit:9634693] Varusai, Thawfeek, 2019-01-14
inferredFrom	[Reaction:9604980] Active Flt3 binds Ptpn11 [Mus musculus]
input	[Complex:9604751] Active FLT3 [plasma membrane] [Homo sapiens] [EntityWithAccessionedSequence:162563] PTPN11 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9604777] Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2 [LiteratureReference:9604970] The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo [LiteratureReference:9649423] Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STAT5 pathways [LiteratureReference:9649425] Roles of tyrosine 589 and 591 in STAT5 activation and transformation mediated by FLT3-ITD
modified	[InstanceEdit:9604991] Varusai, Thawfeek, 2018-04-06 [InstanceEdit:9605256] Varusai, Thawfeek, 2018-04-09 [InstanceEdit:9607241] Varusai, Thawfeek, 2018-05-01 [InstanceEdit:9607299] Varusai, Thawfeek, 2018-05-02 [InstanceEdit:9634820] Varusai, Thawfeek, 2019-01-16 [InstanceEdit:9645140] Varusai, Thawfeek, 2019-05-04 [InstanceEdit:9646277] Varusai, Thawfeek, 2019-05-21 [InstanceEdit:9649422] Varusai, Thawfeek, 2019-06-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Active FLT3 binds PTPN11
output	[Complex:9604972] Active FLT3:PTPN11 [plasma membrane] [Homo sapiens]
precedingEvent	[BlackBoxEvent:9604767] FLT3LG dimer:FLT3 dimer autophosphorylates [Homo sapiens] [Reaction:8854736] FLT3LG dimer:FLT3 binds FLT3 [Homo sapiens]
releaseDate	2019-06-12
reviewed	[InstanceEdit:9645124] Traer, Elie, 2019-05-03 [InstanceEdit:9646275] Joshi, Sunil, 2019-05-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9604989] R-HSA-9604969.3
summation	[Summation:9604977] Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a me...
(hasEvent)	[Pathway:9607240] FLT3 Signaling [Homo sapiens]
(precedingEvent)	[Pathway:5673001] RAF/MAP kinase cascade [Homo sapiens] [Reaction:9645126] Activators bind STAT5 [Homo sapiens] [Pathway:9645135] STAT5 Activation [Homo sapiens]
(updatedInstance)	[_UpdateTracker:9777512] Update Tracker - [Reaction:9604969] Active FLT3 binds PTPN11 - v70:[addLiteratureReference, modifyText]
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No pathways have been reviewed or authored by Active FLT3 binds PTPN11 (9604969)