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Details on Person NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6

Class:Id	BlackBoxEvent:9604831
_displayName	NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6
_doRelease	TRUE
_timestamp	2025-05-27 07:35:16
authored	[InstanceEdit:9604946] Orlic-Milacic, Marija, 2018-04-05
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9604827] Orlic-Milacic, Marija, 2018-04-05
edited	[InstanceEdit:9608067] Orlic-Milacic, Marija, 2018-05-09
goBiologicalProcess	[GO_BiologicalProcess:376439] negative regulation of gene expression
inferredFrom	[BlackBoxEvent:9604833] Notch1 and Notch4 gene transcription is inhibited by Sirt6 [Mus musculus]
input	[DefinedSet:9604882] NOTCH1 gene,NOTCH4 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
modified	[InstanceEdit:9604860] Orlic-Milacic, Marija, 2018-04-05 [InstanceEdit:9604930] Orlic-Milacic, Marija, 2018-04-05 [InstanceEdit:9605465] Orlic-Milacic, Marija, 2018-04-11 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9608068] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9608070] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9608071] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08 [InstanceEdit:9942382] Stephan, Ralf, 2025-03-15 [InstanceEdit:9949961] Stephan, Ralf, 2025-05-27
name	NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6
output	[DefinedSet:9604923] NOTCH1 mRNA,NOTCH4 mRNA [cytosol] [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:9604934] Negative gene expression regulation by 'SIRT6:Nucleosome:NOTCH1,NOTCH4 gene [nucleoplasm]'
releaseDate	2018-06-12
reviewed	[InstanceEdit:9608066] Haw, Robin, 2018-05-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9604844] R-HSA-9604831.3
summation	[Summation:9604857] Based on studies in mice, SIRT6-mediated deacetylation of ly...
(hasEvent)	[Pathway:1912408] Pre-NOTCH Transcription and Translation [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9927644] Negative relationship: NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 [NegativePrecedingEvent:9927647] Negative relationship: NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 [NegativePrecedingEvent:9927648] Negative relationship: NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 [NegativePrecedingEvent:9927649] Negative relationship: NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 [NegativePrecedingEvent:9927650] Negative relationship: NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 [NegativePrecedingEvent:9927652] Negative relationship: NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 [NegativePrecedingEvent:9927654] Negative relationship: NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6
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No pathways have been reviewed or authored by NOTCH1 and NOTCH4 gene transcription is inhibited by SIRT6 (9604831)