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Details on Person SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters

Class:Id	Reaction:9604829
_displayName	SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters
_doRelease	TRUE
_timestamp	2018-05-09 14:10:44
authored	[InstanceEdit:9604946] Orlic-Milacic, Marija, 2018-04-05
catalystActivity	[CatalystActivity:9604902] histone H3K9 deacetylase activity, NAD-dependent of SIRT6:Nucleosome(H3K9ac):NOTCH1,NOTCH4 gene [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9604827] Orlic-Milacic, Marija, 2018-04-05
edited	[InstanceEdit:9608067] Orlic-Milacic, Marija, 2018-05-09
goBiologicalProcess	[GO_BiologicalProcess:376439] negative regulation of gene expression
inferredFrom	[Reaction:9604841] Sirt6 deacetylates histones at Notch1 and Notch4 gene promoters [Mus musculus]
input	[DefinedSet:9604877] SIRT6:Nucleosome(H3K9ac):NOTCH1,NOTCH4 gene [nucleoplasm] [Homo sapiens] [SimpleEntity:427523] NAD+ [nucleoplasm]
isChimeric	FALSE
modified	[InstanceEdit:9604860] Orlic-Milacic, Marija, 2018-04-05 [InstanceEdit:9604916] Orlic-Milacic, Marija, 2018-04-05 [InstanceEdit:9605465] Orlic-Milacic, Marija, 2018-04-11 [InstanceEdit:9608068] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9608070] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9608071] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters
output	[DefinedSet:9604903] SIRT6:Nucleosome:NOTCH1,NOTCH4 gene [nucleoplasm] [Homo sapiens] [SimpleEntity:427498] 2'-O-acetyl-ADP-ribose [nucleoplasm]
precedingEvent	[Reaction:9604834] SIRT6 binds to acetylated histones at NOTCH1 and NOTCH4 gene promoters [Homo sapiens]
releaseDate	2018-06-12
reviewed	[InstanceEdit:9608066] Haw, Robin, 2018-05-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9604845] R-HSA-9604829.2
summation	[Summation:9604856] Based on studies in mice, SIRT6 deacetylates H3 histones on ...
(hasEvent)	[Pathway:1912408] Pre-NOTCH Transcription and Translation [Homo sapiens]
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No pathways have been reviewed or authored by SIRT6 deacetylates histones at NOTCH1 and NOTCH4 gene promoters (9604829)