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Details on Person FLT3LG dimer:FLT3 dimer autophosphorylates

Class:IdBlackBoxEvent:9604767
_displayNameFLT3LG dimer:FLT3 dimer autophosphorylates
_doReleaseTRUE
_timestamp2020-08-21 16:26:42
authored[InstanceEdit:9634693] Varusai, Thawfeek, 2019-01-14
catalystActivity[CatalystActivity:9604755] protein tyrosine kinase activity of FLT3LG dimer:FLT3 dimer [plasma membrane]
compartment[Compartment:876] plasma membrane
created[InstanceEdit:9604761] Varusai, Thawfeek, 2018-04-05
edited[InstanceEdit:9634693] Varusai, Thawfeek, 2019-01-14
input[Complex:8854716] FLT3LG dimer:FLT3 dimer [plasma membrane] [Homo sapiens]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
[SimpleEntity:113592] ATP [cytosol]
isChimericFALSE
literatureReference[LiteratureReference:9604777] Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2
[LiteratureReference:9604740] Oncogenic Flt3 receptors display different specificity and kinetics of autophosphorylation
[LiteratureReference:9604764] A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival
modified[InstanceEdit:9604817] Varusai, Thawfeek, 2018-04-05
[InstanceEdit:9634820] Varusai, Thawfeek, 2019-01-16
[InstanceEdit:9637863] Varusai, Thawfeek, 2019-02-21
[InstanceEdit:9645140] Varusai, Thawfeek, 2019-05-04
[InstanceEdit:9646277] Varusai, Thawfeek, 2019-05-21
[InstanceEdit:9695858] Rothfels, Karen, 2020-07-15
[InstanceEdit:9698053] Wu, G, 2020-08-21
[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
nameFLT3LG dimer:FLT3 dimer autophosphorylates
output[Complex:9604751] Active FLT3 [plasma membrane] [Homo sapiens]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
[SimpleEntity:29370] ADP [cytosol]
precedingEvent
regulatedBy[NegativeRegulation:9695848] Negative regulation by 'FLT3:FLT3-binding type II TKIs [plasma membrane]'
[NegativeRegulation:9695849] Negative regulation by 'FLT3LG dimer:FLT3:FLT3-binding type I TKIs [plasma membrane]'
releaseDate2019-06-12
reviewed[InstanceEdit:9645124] Traer, Elie, 2019-05-03
[InstanceEdit:9646275] Joshi, Sunil, 2019-05-21
reviewStatus[ReviewStatus:9821382] five stars
species[Species:48887] Homo sapiens
stableIdentifier[StableIdentifier:9604784] R-HSA-9604767.4
summation[Summation:9604739] Feline McDonough Sarcoma-like tyrosine kinase (FLT3) is a me...
(hasEvent)[Pathway:9607240] FLT3 Signaling [Homo sapiens]
(precedingEvent)[Reaction:9604738] Active FLT3 dimer binds GRB2 [Homo sapiens]
[Reaction:9604969] Active FLT3 binds PTPN11 [Homo sapiens]
[Reaction:9605259] Active FLT3 binds FYN [Homo sapiens]
[BlackBoxEvent:9609274] Active FLT3 binds HCK [Homo sapiens]
[Reaction:9698408] PTPRJ dephosphorylates active FLT3 [Homo sapiens]
[Reaction:9699578] Active FLT3 phosphorylates CDKN1B [Homo sapiens]
[Reaction:9706287] Active FLT3 binds to ABL2 [Homo sapiens]
[Reaction:9706293] Active FLT3 binds to CBL [Homo sapiens]
[Reaction:9706298] Active FLT3 binds to CSK [Homo sapiens]
[Reaction:9706304] Active FLT3 binds to GRAP2 [Homo sapiens]
List all 18 refering instances
(updatedInstance)[_UpdateTracker:9776763] Update Tracker - [BlackBoxEvent:9604767] FLT3LG dimer:FLT3 dimer autophosphorylates - v74:[addRegulator]
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No pathways have been reviewed or authored by FLT3LG dimer:FLT3 dimer autophosphorylates (9604767)
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