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Details on Person NOTCH4 gene transcription is inhibited by RUNX1

Class:Id	BlackBoxEvent:9604719
_displayName	NOTCH4 gene transcription is inhibited by RUNX1
_doRelease	TRUE
_timestamp	2018-05-09 14:05:13
authored	[InstanceEdit:9604946] Orlic-Milacic, Marija, 2018-04-05
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:9604721] Orlic-Milacic, Marija, 2018-04-05
edited	[InstanceEdit:9608067] Orlic-Milacic, Marija, 2018-05-09
goBiologicalProcess	[GO_BiologicalProcess:376439] negative regulation of gene expression
input	[EntityWithAccessionedSequence:1911501] NOTCH4 gene [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:9604710] Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation
modified	[InstanceEdit:9604726] Orlic-Milacic, Marija, 2018-04-05 [InstanceEdit:9605465] Orlic-Milacic, Marija, 2018-04-11 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9608068] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NOTCH4 gene transcription is inhibited by RUNX1
output	[EntityWithAccessionedSequence:1911475] NOTCH4 mRNA [cytosol] [Homo sapiens]
precedingEvent	[Reaction:9604703] RUNX1 binds NOTCH4 gene [Homo sapiens] [BlackBoxEvent:8935785] RUNX1 mRNA translation is inhibited by miR-17, miR-18a, miR-20a, miR-27a, miR-106a, miR-215, miR-302b, miR-378 and miR-675 [Homo sapiens]
regulatedBy	[NegativeGeneExpressionRegulation:9604723] Negative gene expression regulation by 'RUNX1:NOTCH4 gene [nucleoplasm]'
releaseDate	2018-06-12
reviewed	[InstanceEdit:9608066] Haw, Robin, 2018-05-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9604722] R-HSA-9604719.2
summation	[Summation:9604720] RUNX1 binding to intron 29 of the NOTCH4 gene represses NOTC...
(hasEvent)	[Pathway:1912408] Pre-NOTCH Transcription and Translation [Homo sapiens]
(precedingEvent)	[NegativePrecedingEvent:9927645] Negative relationship: NOTCH4 gene transcription is inhibited by RUNX1 [NegativePrecedingEvent:9927646] Negative relationship: NOTCH4 gene transcription is inhibited by RUNX1 [NegativePrecedingEvent:9927653] Negative relationship: NOTCH4 gene transcription is inhibited by RUNX1
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No pathways have been reviewed or authored by NOTCH4 gene transcription is inhibited by RUNX1 (9604719)