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Details on Person Proteasome degrades ubiquitinated NICD4

Class:Id	BlackBoxEvent:9604642
_displayName	Proteasome degrades ubiquitinated NICD4
_doRelease	TRUE
_timestamp	2018-05-09 14:10:44
authored	[InstanceEdit:9604946] Orlic-Milacic, Marija, 2018-04-05
catalystActivity	[CatalystActivity:174087] endopeptidase activity of 26S proteasome [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9604641] Orlic-Milacic, Marija, 2018-04-04
edited	[InstanceEdit:9608067] Orlic-Milacic, Marija, 2018-05-09
inferredFrom	[BlackBoxEvent:9604648] Proteasome degrades ubiquitinated mouse NICD4 [Homo sapiens]
input	[EntityWithAccessionedSequence:9604624] PolyUb-p-NICD4 [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
modified	[InstanceEdit:9604650] Orlic-Milacic, Marija, 2018-04-04 [InstanceEdit:9608068] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9608071] Orlic-Milacic, Marija, 2018-05-09 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Proteasome degrades ubiquitinated NICD4
output	[DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens] [DefinedSet:68524] Ub [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:9604629] FBXW7 promotes ubiquitination of p-NICD4 [Homo sapiens] [BlackBoxEvent:9604606] Unknown kinase phosphorylates NICD4 [Homo sapiens]
releaseDate	2018-06-12
reviewed	[InstanceEdit:9608066] Haw, Robin, 2018-05-01
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9604643] R-HSA-9604642.2
summation	[Summation:9604646] FBXW7-mediated ubiquitination targets NICD4 (NOTCH4 intracel...
(hasEvent)	[Pathway:9604323] Negative regulation of NOTCH4 signaling [Homo sapiens]
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No pathways have been reviewed or authored by Proteasome degrades ubiquitinated NICD4 (9604642)