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Details on Person Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300

Class:Id	BlackBoxEvent:9604499
_displayName	Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300
_doRelease	TRUE
_timestamp	2018-04-04 16:05:01
authored	[InstanceEdit:1028818] Garapati, P V, 2010-11-18
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9604498] Shamovsky, Veronica, 2018-04-03
edited	[InstanceEdit:9604498] Shamovsky, Veronica, 2018-04-03
input	[DefinedSet:1027363] Type-I IFN genes [nucleoplasm] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:1027380] Differential viral induction of distinct interferon-alpha genes by positive feedback through interferon regulatory factor-7 [LiteratureReference:994024] Regulation of immune cell homeostasis by type I interferons
modified	[InstanceEdit:9604503] Shamovsky, Veronica, 2018-04-03 [InstanceEdit:9604604] Shamovsky, Veronica, 2018-04-04 [InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300
output	[DefinedSet:909690] IFN alpha/beta (IFNA/B) [extracellular region] [Homo sapiens]
precedingEvent	[Reaction:1028819] VAF/pIRF7:CBP/p300 binds the promoters of type-I IFN genes [Homo sapiens] [Reaction:1028820] Formation of VAF (virus-activated factor) complex [Homo sapiens] [Reaction:933536] p-IRF7 dimer interacts with coactivator CBP/p300 [Homo sapiens]
regulatedBy	[PositiveGeneExpressionRegulation:9604496] Positive gene expression regulation by 'VAF/pIRF7:CBP/p300 bound to type I IFN gene promoter [nucleoplasm]'
releaseDate	2010-12-14
reviewed	[InstanceEdit:990527] Kawai, T, Akira, S, 2010-10-30
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9604500] R-HSA-9604499.2
summation	[Summation:9604497] The Interferon alpha and beta genes are transcribed and tran...
(hasEvent)	[Pathway:933541] TRAF6 mediated IRF7 activation [Homo sapiens]
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No pathways have been reviewed or authored by Expression of Interferon-alpha and beta mediated by VAF/pIRF7:CBP/p300 (9604499)