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Details on Person p-IRF7 dimers are then transported into the nucleus and asse...
| Class:Id | Summation:9604489 |
|---|---|
| _displayName | p-IRF7 dimers are then transported into the nucleus and asse... |
| _timestamp | 2018-04-03 18:07:45 |
| created | [InstanceEdit:9604488] Shamovsky, Veronica, 2018-04-03 |
| literatureReference | [LiteratureReference:3134870] Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells |
| modified | [InstanceEdit:9604495] Shamovsky, Veronica, 2018-04-03 |
| text | p-IRF7 dimers are then transported into the nucleus and assemble with the coactivator CBP/p300 to activate transcription of type I interferons and other target genes. DExH/D-box helicase 36 (DHX36)-mediated sensing of CpG-A trigger downstream signaling to activation of interferon regulatory transcription factor 7 (IRF7). Knockdown of DHX36 expression by RNA interference in the CpG-A-treated human plasmacytoid dendritic cell line Gen2.2 inhibited nuclear localization of IRF7 (Kim T et al. 2010). |
| (summation) | [Reaction:9604487] p-IRF7:p-IRF7 translocates to the nucleus [Homo sapiens] |
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