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Details on Person p-IRF7:p-IRF7 translocates to the nucleus

Class:Id	Reaction:9604487
_displayName	p-IRF7:p-IRF7 translocates to the nucleus
_doRelease	TRUE
_timestamp	2022-02-14 06:58:22
authored	[InstanceEdit:918228] Garapati, P V, 2010-08-02
compartment	[Compartment:13231] nuclear envelope
created	[InstanceEdit:9604488] Shamovsky, Veronica, 2018-04-03
edited	[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
input	[Complex:450344] p-2S-IRF7:p-2S-IRF7 [cytosol] [Homo sapiens]
isChimeric	FALSE
literatureReference	[LiteratureReference:933500] Phosphorylation-induced dimerization of interferon regulatory factor 7 unmasks DNA binding and a bipartite transactivation domain [LiteratureReference:933439] Structural insights into interferon regulatory factor activation [LiteratureReference:3134870] Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells
modified	[InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9764722] Shamovsky, Veronica, 2022-02-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	p-IRF7:p-IRF7 translocates to the nucleus
negativePrecedingEvent	[NegativePrecedingEvent:9764721] Incorrect Order: DHX36 or DHX9 binds MyD88
output	[Complex:450306] 2xp-S477,S479-IRF7 [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:933533] Dimerization of p-IRF7 [Homo sapiens] [Reaction:933525] Phosphorylation and release of IRF7 [Homo sapiens] [Reaction:975106] Phosphorylation and release of IRF7 upon TLR7/8 or 9 activation [Homo sapiens]
regulatedBy	[PositiveRegulation:3134857] Positive regulation by 'DHX36:CpG:MyD88 [cytosol]'
releaseDate	2010-12-14
reviewed	[InstanceEdit:3597627] Jin, Lei, 2013-05-21 [InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
reviewStatus	[ReviewStatus:9821382] five stars
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9604490] R-HSA-9604487.3
summation	[Summation:9604489] p-IRF7 dimers are then transported into the nucleus and asse...
(hasEvent)	[Pathway:3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production [Homo sapiens]
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No pathways have been reviewed or authored by p-IRF7:p-IRF7 translocates to the nucleus (9604487)