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Details on Person NFkB complex translocates from the cytosol to the nucleus

Class:Id	Reaction:9604480
_displayName	NFkB complex translocates from the cytosol to the nucleus
_doRelease	TRUE
_timestamp	2022-02-14 06:52:45
authored	[InstanceEdit:450362] Shamovsky, V, 2009-12-16
compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:9604478] Shamovsky, Veronica, 2018-04-03
edited	[InstanceEdit:3465604] Shamovsky, V, 2013-05-17
input	[Complex:168155] NFKB1(1-433), NFKB2(1-454):RELA [cytosol] [Homo sapiens]
literatureReference	[LiteratureReference:3134870] Aspartate-glutamate-alanine-histidine box motif (DEAH)/RNA helicase A helicases sense microbial DNA in human plasmacytoid dendritic cells [LiteratureReference:202538] The two NF-kappaB activation pathways and their role in innate and adaptive immunity [LiteratureReference:202509] Ubiquitin signalling in the NF-kappaB pathway [LiteratureReference:1606323] DAI/ZBP1 recruits RIP1 and RIP3 through RIP homotypic interaction motifs to activate NF-kappaB
modified	[InstanceEdit:9606200] Wu, G, 2018-04-19 [InstanceEdit:9764698] Shamovsky, Veronica, 2022-02-14 [InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NFkB complex translocates from the cytosol to the nucleus
negativePrecedingEvent	[NegativePrecedingEvent:9764697] Incorrect Order: DHX36 or DHX9 binds MyD88
output	[Complex:177673] NFKB1(1-433), NFKB2(1-454):RELA [nucleoplasm] [Homo sapiens]
precedingEvent	[Reaction:168140] Active IKK Complex phosphorylates NF-kappa-B inhibitor [Homo sapiens] [Reaction:168910] RIP1 facilitates IKK complex phosphorylation [Homo sapiens] [Reaction:168184] Activated TAK1 mediates phosphorylation of the IKK Complex [Homo sapiens] [Reaction:933530] Activation of IKK by MEKK1 [Homo sapiens] [Reaction:9630923] NF-kappa-B inhibitor binds NF-kappa-B complex [Homo sapiens]
regulatedBy	[PositiveRegulation:3134865] Positive regulation by 'DHX9:CpG:MyD88 [cytosol]'
releaseDate	2010-12-14
requiredInputComponent	[Complex:157689] Nuclear Pore Complex (NPC) [nuclear envelope] [Homo sapiens]
reviewed	[InstanceEdit:2023355] D'Eustachio, P, 2011-12-07 [InstanceEdit:3597627] Jin, Lei, 2013-05-21 [InstanceEdit:3597624] Wu, Jiaxi, 2013-05-21
reviewStatus	[ReviewStatus:9821382] five stars
revised	[InstanceEdit:442879] Shamovsky, V, 2009-09-29
species	[Species:48887] Homo sapiens
stableIdentifier	[StableIdentifier:9604481] R-HSA-9604480.3
summation	[Summation:9604479] NFkB is a family of transcription factors that play pivotal ...
(hasEvent)	[Pathway:1810476] RIP-mediated NFkB activation via ZBP1 [Homo sapiens] [Pathway:3134963] DEx/H-box helicases activate type I IFN and inflammatory cytokines production [Homo sapiens]
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No pathways have been reviewed or authored by NFkB complex translocates from the cytosol to the nucleus (9604480)