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Details on Person AKT1-mediated phosphorylation of NOTCH4 intracellular domain...
| Class:Id | Summation:9604396 |
|---|---|
| _displayName | AKT1-mediated phosphorylation of NOTCH4 intracellular domain... |
| _timestamp | 2018-04-03 09:05:34 |
| created | [InstanceEdit:9604395] Orlic-Milacic, Marija, 2018-04-03 |
| literatureReference | [LiteratureReference:9604316] AKT and 14-3-3 regulate Notch4 nuclear localization |
| modified | [InstanceEdit:9604405] Orlic-Milacic, Marija, 2018-04-03 |
| text | AKT1-mediated phosphorylation of NOTCH4 intracellular domain fragment NICD4 leads to binding of NICD4 to 14-3-3-zeta (YWHAZ). Binding to YWHAZ sequesters NICD4 to the cytosol, preventing its trafficking to the nucleus, and thus negatively regulates NOTCH4 signaling (Ramakrishnan et al. 2015). |
| (summation) | [Reaction:9604387] p-4S-NICD4 binds YWHAZ [Homo sapiens] |
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No pathways have been reviewed or authored by AKT1-mediated phosphorylation of NOTCH4 intracellular domain... (9604396)
